放疗致肺癌患者发生放射性肺炎的影响因素研究

Study on Influencing Factors of Radiation Pneumonia in Patients With Lung Cancer Caused by Radiotherapy

目的探究放疗致肺癌患者发生放射性肺炎的影响因素。方法回顾性分析96例肺癌患者临床资料,均接受放疗,出现放射性肺炎36例。对发生放射性肺炎的影响因素进行分析。结果放射性肺炎出现率为37.50%;男女出现放射性肺炎的比例差异不存在统计学意义(P>0.05),>50岁、体力状况(KPS)<60分、有吸烟史、小细胞肺癌、放疗靶体积≥300 cm3、肿瘤剂量≥66 Gy的患者出现放射性肺炎的比例远高于≤50岁及以下、KPS评分≥60分、无吸烟史、非小细胞肺癌、放疗靶体积<300 cm3、肿瘤放射剂量<66 Gy的患者(P<0.05)。结论放疗致肺癌患者发生放射性肺炎的影响因素是多方面的,在制定放疗计划时要综合考虑患者情况。

Objective To explore the influencing factors of radiation pneumonia in patients with lung cancer caused by radiotherapy. Methods The clinical data 96 cases of lung cancer was retrospective analyzed, they were treated with radiotherapy, including the emergence of radiation pneumonia in 36 cases. The influencing factors of radiation pneumonia were analyzed. Results Radiation pneumonitis occurred in 37.50% of patients; the proportion of radiation pneumonia in patients who were aged 〉 50 years old, KPS 〈60 points, smoking history, small cell lung cancer, radiotherapy target volume ≥300 cm^3, tumor dose≥66 Gy was much higher than that of patients who were aged ≤ 50 years and below, KPS score ≥60 points, no smoking history, non-small cell lung cancer, radiotherapy target volume 〈300 cm^3, tumor dose 〈66 Gy （P 〈 0.05）. Conclusion There are many factors influencing the occurrence of radiation pneumonia in patients with lung cancer caused by radiotherapy. In the development of radiotherapy plan, we should consider the situation of patients.