甘精胰岛素联合口服降糖药治疗2型糖尿病的临床疗效观察

Clinical Observation of Insulin Glargine Combined With Oral Hypoglycemic Agents in the Treatment of Type 2 Diabetes

目的探讨甘精胰岛素联合口服降糖药治疗口服降糖药血糖控制不理想的2型糖尿病的临床疗效。方法选取本院接受治疗的84例口服降糖药血糖控制不理想的2型糖尿病患者,随机分成2组,各42例,其中观察组给予甘精胰岛素注射液联合格列吡嗪控释片与二甲双胍片治疗,对照组给予精蛋白锌重组人胰岛素注射液联合格列吡嗪控释片与二甲双胍片治疗,观察两组患者的临床疗效。结果观察组患者治疗6周后、12周后的糖化血红蛋白水平、空腹血糖浓度、餐后2小时血糖浓度均低于对照组,治疗12周后的空腹C肽水平、餐后2小时C肽水平均高于对照组,治疗12周后的身体质量指数、胰岛素用量以及低血糖发生率低于对照组(P<0.05)。结论甘精胰岛素联合口服降糖药治疗口服降糖药血糖控制不理想的2型糖尿病患者能有效控制患者的血糖水平和体质量,效果明显,不良反应少。

Objective To investigate the clinical efficacy of insulin glargine combined with oral hypoglycemic agents in the treatment of type 2 diabetes mellitus with poor glycemic control of oral hypoglycemic agents.Methods 84 patients with type 2 diabetes mellitus with poor glycemic control of oral hypoglycemic agents were randomly divided into two groups（n=42）.The patients in the observation group were treated with insulin glargine combined with glipizide and metformin tablets,the control group was treated with protamine zinc recombinant human insulin injection combined with glipizide controlled release tablets and metformin tablets treatment,the clinical efficacy of the two groups of patients was observed.Results After six weeks and twelve weeks of treatment,the levels of glycosylated hemoglobin,fasting blood glucose and 2 h postprandial blood glucose levels in the observation group were lower than those of the control group respectively,after twelve weeks of treatment,the fasting C peptide level and 2 h postprandial C peptide level of treatment was higher than the control group（P〈0.05）.After twelve weeks of treatment,the body weight index,the amount of insulin and the incidence of adverse reactions in the observation group were lower than those of the control group（P〈0.05）.Conclusion Glucose insulin combined with oral hypoglycemic agents can effectively control the blood glucose level and body weight of patients with type 2 diabetes mellitus with poor glycemic control of oral hypoglycemic agents.The effect is obvious and the adverse reactions are fewer.