耐药性肺结核左氧氟沙星与莫西沙星治疗的效果对比观察

Comparison of the Effect of Levofloxacin and Moxifloxacin in the Treatment of Drug-resistant Tuberculosis

目的比较观察左氧氟沙星和莫西沙星在耐药性肺结核治疗中的效果。方法选择我院2015年7月—2016年7月收治的82例耐药性肺结核患者作为本次研究对象,并按照数字表法进行随机分组,每组41例。在相同基础方案治疗的前提下,Ⅰ组患者使用莫西沙星治疗、Ⅱ组患者使用左氧氟沙星治疗,比较两组患者治疗情况、痰菌转阴与空洞改善情况。结果Ⅰ组患者治疗整体有效率95.1%,比Ⅱ组患者高(P<0.05),且Ⅰ组患者在各阶段痰菌转阴率与空洞改善情况皆要好于Ⅱ组患者(P<0.05)。结论和左氧氟沙星比较,使用莫西沙星治疗耐药性肺结核的效果更好,能增加患者痰菌转阴率、更好地改善空洞情况。

Objective To observe the effect of levofloxacin and moxifloxacin in the treatment of drug-resistant tuberculosis.Methods A total of 82 patients with tuberculosis were enrolled in our hospital from July 2015 to July 2016 as subjects of this study and randomized to 41 patients in each group.In the same basic program under the premise of treatment,patients in group Ⅰ were treated with moxifloxacin,patients in Ⅱ group were treated with levofloxacin,the treatment effect,sputum negative rate and cavities improvement between two groups were compared.Results The overall effective rate of group Ⅰ was 95.1%,higher than that of group Ⅱ（P〈0.05）,and the improvement negative rate of sputum and cavity in group Ⅰ were better than that in group Ⅱ（P〈0.05）.Conclusion Compared with levofloxacin,the use of moxifloxacin in the treatment of drug-resistant tuberculosis is better,can increase the rate of sputum,and better improve the cavity.