摘要
砷是一种广泛存在于自然环境中的化学污染物，国际癌症研究机构（IARC）已经明确砷及其化合物是人类致癌物，地方性砷中毒也成为了严重危害人类健康的公共卫生问题。然而，砷代谢及其毒性作用的种属差异很大，未能在动物上直接复制出合适的致癌模型，没有一个公认的砷致癌机制。作者从砷代谢、砷遗传毒性、砷诱导表观遗传学改变、砷引起细胞信号通路改变、砷与雌激素受体表达以及砷免疫毒性等方面做简要综述，为地方性砷中毒的防治提供参考。
Arsenic is one of the chemical pollutants, which is widely distributed in natural environment. International agency for research on cancer （IARC） has made it clear that arsenic and its compounds are carcinogens; endemic arseniasis has become a public health problem that seriously endangers human health. However, the arsenic metabolic and toxic effects of the species vary widely, failure to replicate a suitable carcinogenic model on animals, and there is no recognized carcinogenic mechanism. The author provide a brief review of arsenic metabolism, arsenic genotoxicity, arsenic-induced epigenetic changes, arsenic-induced changes in cell signaling pathways, arsenic and estrogen receptor expression, and arsenic immunotoxicity, to provide a reference for control and prevention of endemic arseniasis.
出处
《中华地方病学杂志》
CSCD
北大核心
2017年第12期933-936,共4页
Chinese Journal of Endemiology
基金
国家自然科学基金（81673207）
大学生创新创业训练计划项目（201710159000097）
