摘要
目的用倾向评分配比分析探讨充分水化对冠状动脉造影术(CA)或经皮冠状动脉介入治疗术(PCI)所致对比剂肾病(CIN)的预防作用。方法以2010年首都医科大学附属北京安贞医院3993例行CA或PCI的患者为研究对象,并以是否按照2006年"国际对比剂肾病专家共识"建议的方案进行了水化处理将上述患者分为充分水化(48例)和未行水化(共3945例)两类,而后应用倾向评分匹配法从未行水化患者中筛选出与充分水化患者匹配的等数量(48例)患者,构成了本研究的充分水化组及未水化组(各48例)。观察并比较了这两组患者的术后CIN发生率、院内不良事件发生率及全因死亡率。结果未水化组的CIN发病率为16.7%(8/48例),充分水化组为0,两组比较差异具有统计学意义(P=0.006);未水化组的院内不良事件发生率为2.1%,充分水化组为0,但两组间差异尚无统计学意义(P=1.000);两组均无死亡病例。结论充分水化处理可有效预防CIN发生。
Objective To investigate the effects of adequate hydration on prevention of contrast-induced nephropathy (CIN), through propensity score matching analysis, in the hospitalized patients undergoing coronary angiography (CA) or percutaneous coronary intervention (PCI). Methods A total of 3993 patients hospitalized in Beijing Anzhen Hospital in 2010 were collected. Among them, 48 patients accepted adequate hydration and 3945 patients did not accept hydration. Using propensity score matching method 48 patients without hydration, who matched with the adequately hydrated patients, were screened out. In this way, the adequate hydration group and the non-hydration group (48 patients in each group) in this study were formed. 2-he incidence of CIN, the adverse events and mortality during hospitalization were observed and compared between these two groups. Results The incidence of CIN was 16.7% in the non-hydration group and 0 in the adequate hydration group (P=0.006). The incidence of in-hospital adverse events was 2.1% in the non-hydration group and 0 in the adequate hydration group (P=1.000). No patients died in both groups. Conclusion Adequate hydration can effectively prevent CIN.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2017年第12期1086-1089,共4页
Chinese Journal of Practical Internal Medicine
基金
首都卫生发展科研专项(首发2011-2006-07)
关键词
水化处理
对比剂肾病
冠状动脉造影术
经皮冠状动脉介入治疗术
hydration treatment
contrast-induced nephropathy
coronary angiography
percutaneous coronary intervention