摘要
目的:评价早期神经功能改善与急性缺血性卒中患者发病90 d后预后的关系。方法:回顾性分析急性缺血性脑卒中并接受重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗患者的临床资料。所有患者溶栓前和溶栓后1 h采用美国国立卫生研究院卒中量表(NIHSS)进行评分。将早期神经功能改善定义为溶栓后1h NIHSS评分减少≥5分或NIHSS评分=0分,用改良Rankin量表(mRS)评分来评估90 d预后,运用Logistic回归模型来分析患者早期神经功能改善和90 d预后的相关性。结果:纳入94例患者,在溶栓后1 h,早期神经功能改善27例(28.72%)。多因素Logistic回归分析提示,早期神经功能改善是90 d良好预后的独立预测因子(OR 6.79;95%CI 1.73~26.61,P<0.01)。结论:急性缺血性卒中患者接受rt-PA静脉溶栓后,早期神经功能改善则90 d后具有良好预后。
Objective: To evaluate the relationship between the improvement of early neurological function and the prognosis of patients with acute ischemic stroke after onset of 90 d. Methods: All patients underwent throm- bolysis prior to thrombolysis with a National Institutes of Health Stroke Scale (NIHSS) score, retrospectively analyzed for acute ischemic stroke and received intravenous thrombolysis with recombinant tissue plasminogen acti- vator (rt-PA), 1 h after thrombolysis NIHSS score. The improvement of early neurological function was defined as 1h after thrombolysis NIHSS score reduction ≥5 points or NIHSS score = 0, with modified Rankin scale (mRS) score to evaluate the 90 d prognosis, The use of Logistics regression model to analyze the correlation between early neurological improvement and prognosis at 90 days in patients. Results: Ninety-four patients were enrolled in this study. In the In'st hour after thrombolysis, there were 27 cases (28.72%) of early neurological improvement..Multivariate Logistic regression analysis showed that early neurological improvement was an independent predictor of 90-day good prognosis (OR 6.79; 95% CI1.73-26.61, P〈0.01). Conclusion: After rt-PA intravenous thrombolysis, acute ischemic stroke patients with early neurological improvement after 90 d had a good prognosis.
出处
《神经损伤与功能重建》
2017年第6期497-500,共4页
Neural Injury and Functional Reconstruction
关键词
急性缺血性卒中
溶栓
预后
早期神经功能改善
acute ischemic stroke
thrombolysis
outcome
early neurologic improvement