摘要
目的:探讨脑梗死患者血浆中同型半胱氨酸、维生素B_(12)与叶酸表达水平与血管性痴呆的关系。方法:采用高效液相色谱法检测受试者(脑梗死患者血管性痴呆组、脑梗死患者非痴呆组、健康对照组)血浆Hcy、维生素B_(12)及叶酸水平,并观察MTHFR基因型在不同组间分布情况。结果:血管性痴呆组的血浆Hcy水平明显高于非痴呆组、健康对照组(P<0.05),而维生素B_(12)及叶酸水平明显低于非痴呆组和健康对照组(P<0.05)。不同病情严重程度脑梗死血管性痴呆患者间Hcy、维生素B_(12)及叶酸水平无统计学差异(P>0.05)。MTHFR基因型在各组间分布情况差异也无统计学意义(P>0.05)。结论:血浆中Hcy、维生素B_(12)及叶酸水平可能与血管性痴呆有关。
Objective： To investigate relations between plasma homocysteine, vitamin B12, folic acid levels and vascular dementia in cerebral infarction patients. Methods： The plasma homocysteine, vitamin B12, folic acid levels of vascular dementia group, non-infaret dementia group and health control group were analyzed by using HPLC. The polymorphisms of methylenetetrahydrofolate （MTHFR） reductase gene in different group were also observed. Results： The plasma homocysteine levels of vascular dementia group were much higher than those of non-infarct dementia group and health control group （P〈0.05）, while the vitamin B12, folio acid levels of vascular dementia group were much lower than those of non-infarct dementia group and health control group （P〈 0.05）. There were no significant differences in level of homocysteine, vitamin B12 and folate between different level of vascular dementia group（P〉0.05）. The polymorphisms of MTHFR reductase gene in the different groups showed no significant differences（P〉0.05）. Conclusion： The plasma homocysteine, vitamin B12, and folic acid levels have relations with vascular dementia.
出处
《神经损伤与功能重建》
2017年第6期507-510,共4页
Neural Injury and Functional Reconstruction
