活动性肺结核患者的血液流变性改变

Changes of Hemorrheology in 36 Patients with Active Pulmonary Tuberculosis

目的观察活动性肺结核患者血液流变学的变化。方法应用Liang-100微机显示自动记录血液血浆粘度计、细胞电泳计时器、变温控温仪 ,测定25℃时的全血比粘度、血浆粘度、全血还原粘度、血沉、红细胞比容、红细胞电泳时间。同时用物理法测定血浆纤维蛋白原含量。结果和32例健康者相应的血液流变学参数比较 ,36例肺结核患者的全血比粘度(低切速)、血浆比粘度、全血还原粘度(低切速)均明显增高(P<0.01) ,血沉加快(P<0.01),红细胞电泳时间减慢(P<0.05) ;同时活动性肺结核进展期患者的血浆粘度显著高于好转期患者(P<0.01)。结论活动性肺结核患者存在高粘滞综合征 。

Objective To investigate the changes of hemorrheology in patients with active pulmonary tuberculosis. Method The hemorrheological parameters (whole blood relative viscosity, plasma viscosity, whole blood reducing viscosity, erythrocyte sedimentation rate, packed red cell volume,and red cell electrophoresis) were measured by automatic-recorded blood and plasma viscosity (model Liang-100) at 25℃. Meanwhile, plasma fibrinogen was measured. Results The results showed that the whole blood relative viscosity ( in low shear rate) plasma relative viscosity and the whole blood reducing viscosity in active tuberculosis group (n=36) were obviously higher than those in normal group(n=32),P<0.01. The erythrocyte sedimentation rate was quickened and electrophoresis slowed(P<0.05). The plasma viscosity in progressive stage of active pulmonary tuberculosis was evidently higher than that in resolving stage(P<0.01). Conclusions The patients with active pulmonary tuberculosis suffered from hyperviscosity syndrome and hemorrheological changes became more prominent in progressive stage.