盐酸氨溴索片与噻托溴铵粉吸入剂对慢性阻塞性肺疾病患者的疗效及其对肺功能的影响

Clinical Efficacy of Combined Ambroxol Hydrochloride and Thiotobromide Inhalation and Influence on Lung Function in Patients with COPD

目的:评价盐酸氨溴索片与噻托溴铵粉吸入剂对老年患者慢性阻塞性肺疾病(COPD)的临床疗效及其对肺功能的影响。方法:选取2016年3月—2017年3月间呼吸内科收治的COPD患者120例临床资料,将其分为观察组60例和对照组60例;对照组患者在常规治疗(吸氧、消炎、祛痰、镇咳等)的基础上加用噻托溴铵粉吸入剂治疗,观察组患者在对照组治疗基础上加用盐酸氨溴索片治疗,比较两组患者治疗后总有效率的差异以及治疗前后肺功能各指标测得值的变化情况。结果:观察组患者治疗后的总有效率为96.67%高于对照组为75.00%(P<0.05);治疗后两组患者的FEV1、FVC、FEV1/FVC各测得值高于治疗前(P<0.05);观察组患者治疗后FEV1、FVC、FEV1/FVC各测得值高于对照组(P<0.05)。结论:采用盐酸氨溴索片与噻托溴铵粉吸入剂治疗老年患者COPD的临床疗效优于单用噻托溴铵粉吸入剂的疗效,有效改善了肺功能各指标,增加了肺部通气量,缓解了COPD患者呼吸困难和供氧不足的症状。

Objective： To evaluate the clinical efficacy of combined ambroxol hydrochloride and thiotobromide powder inhalation and influence of lungs function in patients with COPD. Methods： The clinical data of 120 cases of COPD patients admitted to respiratory medicine from March 2016 to March 2017 were selected. 120 patients with COPD were randomly divided into observation group of 60 cases and control group of 60 cases. Patients in the control group were treated with routine therapy（oxygen, anti-inflammation, expectorants, antitussives, etc.）, plus with thiotobromide powder inhalation agent. Patients in the observation group were treated by the therapy of control group, plus with ambroxol hydrochloride tablet. After the treatment, the changes of total effective rate and measured values of lung function indexes of patients in two groups were compared. Results： After treatment, first of all, the total effective rate of observation group was 96.67%. It was higher than that of control group, which was 75.00% （P〈0.05）. In addition, FEV1, FVC and FEV1/FVC of patients in two groups were all higher than those before treatment （P〈0.05）. At last, FEV1, FVC and FEV1/FVC of patients in observation group were higher than those of patients in control group. Conclusion： The clinical efficacy of combined ambroxol hydrochloride tablet and thiotobromide powder inhalation is better than that using thiotobromide powder inhalation agent alone. The indexes of pulmonary function were improved noticeably. Pulmonary ventilation volume was increased. And the symptoms of dyspnea and lack of oxygen of COPD patients were eased.