摘要
目的 :观察三七二醇苷 (PDS)对大鼠实验性心肌缺血再灌注损伤的影响。方法 :采用结扎大鼠冠状动脉 30分钟后 ,再接通 6 0分钟 ,造成心肌缺血再灌注损伤模型 ,测定动脉血压、心律失常发生率、心律失常严重指数 (ASI)、心肌组织中丙二醛 (MDA)含量、超氧化物歧化酶 (SOD)及ATPase活性、血清中乳酸脱氢酶 (LDH)水平。结果 :预防性静注PDS(5 0mg .kg- 1 )可显著降低再灌注心律失常发生率、心肌组织中MDA含量和血清中LDH的水平 ;明显改善再灌注后动脉血压的下降 ,心肌组织中SOD及ATPase活性降低。结论
In order to observe the effects of panaxadiol saponins(PDS) isolated from Panax notoginseng on myocardial ischemia reperfusion.Methods:The experimental model was established by ligaturing coronary artery for 30 minutes followed by reperfusing for 60 minutes in the rats.The artery blood pressure, rate of reperfusion arrhythmias,arrhythmias severity index(ASI),level of malonaldehyde(MDA),activity of superoxide dismutase(SOD)and ATP ase in myocardium,and level of lactic dehydrogenase(LDH)in serum were measured.Results:PDS(50 mg·kg -1 ·iv)significantly decreased reperfusion arrhythmias and ASI.Inhibited failure of myocardial function.Decreased level of MDA and improved activity of SOD in myocardium,and decreased LDH level in serum after reperfusion. Conclusion:PDS might have a protective effect on the damage of myocardial ischemia reperfusion in rats.
出处
《湖北中医学院学报》
2002年第3期26-27,共2页
Journal of Hubei College of Traditional Chinese Medicine
