不同剂量阿托伐他汀在冠心病治疗中的疗效及不良反应

Clinical effect and adverse reaction of different doses of atorvastatin in the treatment of coronary heart disease

目的探讨不同剂量阿托伐他汀在冠心病治疗中的疗效及不良反应。方法选取我院2016年9月至2017年1月收治的60例冠心病患者,随机分为试验组与对照组,各30例。试验组患者给予40 mg阿托伐他汀进行治疗,对照组患者给予20 mg阿托伐他汀进行治疗。比较两组患者的临床效果及不良反应发生情况。结果治疗后,两组患者的TG、TC及HDL-C水平明显优于治疗前,且试验组患者明显优于对照组,差异具有统计学意义(P<0.05)。对照组不良反应总发生率为20.00%,试验组不良反应总发生率为23.33%,两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论不同剂量阿托伐他汀治疗冠心病,剂量越大,治疗效果越明显,而不良反应并未因剂量的增大而增加。

Objective To evaluate the efficacy and adverse effects of different doses of atorvastatin in the treatment of coronary heart disease. Methods Sixty cases of patients with coronary heart disease admitted in our hospital from September 2016 to January 2017 were selected and randomly divided into experimental group and control group, with 30 cases in each group. The experimental group was treated with 40 mg atorvastatin, and the control group was treated with 20 mg atorvastatin.The clinical effects and adverse reactions were compared between the two groups. Results After treatment, the levels of TG,TC and HDL-C of the two groups were better than those before treatment, and those of the experimental group were better than the control group, the differences were statistically significant（P〈0.05）. In the control group, the total incidence of adverse reactions was 20.00%, and that in the experimental group was 23.33%, there was no significant difference between the two groups（P〉0.05）. Conclusion Different doses of atorvastatin in the treatment of coronary heart disease, the greater the dose, the more obvious treatment effect, and the incidence of adverse reactions doesn＇t increase with the increasing drug dose.