不同β-受体阻滞剂在心室收缩不同步特发性扩张型心肌病治疗中的效果分析

Clinical effects of different β-blockers in the treatment of ventricular systolic asynchrony in patients with idiopathic dilated cardiomyopathy

目的探讨心室收缩不同步特发性扩张型心肌病(IDC)采用不同β-受体阻滞剂进行治疗的临床效果。方法选择我院在2011年5月至2016年5月收治的60例IDC患者为研究对象,将所有患者按照治疗方法分为对照组和研究组,每组30例。对照组患者采用美托洛尔进行治疗,研究组则采用卡维地洛进行治疗。对比两组患者治疗总有效率及不良反应发生率。结果经过治疗之后,研究组总有效率(93.33%)明显高于对照组(70.00%),不良反应总发生率(6.67%)明显低于对照组(30.00%),差异均具有统计学意义(P<0.05)。结论采用美托洛尔与卡维地洛对IDC患者进行治疗,均能够改善患者的临床症状,但是采用卡维地洛治疗临床效果明显较佳,且安全性较高,可进一步推广使用。

Objective To investigate the clinical efficacy of different β-blockers in the treatment of ventricular systolic asynchrony in patients with idiopathic dilated cardiomyopathy（IDC）. Methods Sixty cases of ventricular systolic asynchrony patients with IDC admitted in our hospital from May 2011 to May 2016 were selected as the study objects,and all the patients were divided into control group and study group according to the treatment methods, with 30 cases in each group. Patients in the control group were treated with metoprolol, while patients in the study group were treated with carvedilol. The total effective rates and incidences of adverse reactions were compared between the two groups.Results After treatment, the total effective rate of the study group（93.33%） was significantly higher than that of the control group（70.00%）（P〈0.05）; the total incidence rate of adverse reactions in the study group（6.67%） was significantly lower than that in the control group（30.00%）, there were statistically significant differences（ P〈0.05）. Conclusion Metoprolol and carvedilol applied in the treatment of ventricular systolic asynchrony patients with IDC both can improve the clinical symptoms of the patients, but the clinical effect of carvedilol treatment is better, it has higher security, which can be further widely used.