经皮穴位电刺激治疗慢性疲劳综合征:随机对照研究

Chronic fatigue syndrome treated with transcutaneous electrical acupoint stimulation: a randomized controlled trial

目的:评价任督脉经穴经皮穴位电刺激(TEAS)治疗慢性疲劳综合征的临床疗效及安全性。方法:将89例慢性疲劳综合征患者随机分为观察组(46例)、对照组(43组)。观察组采用经皮穴位电刺激大椎与命门、神阙与关元[电流强度(14±2)m A],对照组进行与观察组相同穴位模拟经皮穴位电刺激(电流强度1 m A),两组均每次30 min,每天1次,每周5次,4周为一疗程,共1个疗程。治疗前及1个疗程结束后,采用疲劳严重程度量表(fatigue severity scale,FSS)评价患者疲劳症状,躯体及心理健康报告(somatic and psychological health report,SPHERE)评价潜在症状,同时观察TEAS疗法安全性。结果:治疗结束后,对照组FSS评分及SPHERE评分与治疗前比较差异均无统计学意义(均P>0.05),观察组FSS评分及SPHERE评分较治疗前均显著下降(均P<0.001),且观察组FSS评分及SPHERE评分较对照组下降明显(均P<0.001);整个治疗过程中经皮穴位电刺激治疗未出现不良事件。结论:任督脉经穴经皮穴位电刺激能改善慢性疲劳综合征患者的疲劳症状和潜在症状,具有良好的安全性。

Objective To evaluate the clinical therapeutic effects and safety of chronic fatigue syndrome treated with transcutaneous electrical acupoint stimulation （TEAS） on the conception vessel and the governor vessel. Methods Eighty-nine patients of chronic fatigue syndrome were randomized into an observation group （46 cases） and a control group （43 cases）. In the observation group, TEAS was applied at Dazhui （GV 14） and Mingmen （GV 4）, Shenque （CV 8） and Guanyuan （CV 4） [the current intensity： （14 ~ 2） mA]. In the control group, the simulated TEAS was applied at the same acupoints as the observation group （the current intensity： 1 mA）. The treatment was given for 30 min, once a day, 5 times a week and the treatment of 4 weeks was as 1 session in the two groups. One session of treatment was required. Before treatment and at the end of 1 session of treatment, the fatigue severity scale （FSS） was adopted to evaluate the fatigue symptoms and the somatic and psychological health report （SPHERE） was adopted to evaluate the potential symptoms and observe the safety of TEAS therapy. Results At the end of treatment, FSS score and SPHERE score in the control group were not different significantly as compared with those before treatment （both P〉 0.05）. FSS score and SPHERE score in the observation group were reduced significantly as compared with those before treatmen! （both P〈 0.01）. FSS score and SPHERE score in the observation group were reduced apparently as compared with those in the control group （both P〈 0.001）. In the entire process of treatment with TEAS, no any adverse reaction occurred. Conclusion TEAS on the conception vessel and the governor vessel relieves fatigue symptoms and the potential symptoms in the patients of chronic fatigue syndrome. It is a safe therapy.