针刺治疗多囊卵巢综合征合并不孕症是否真的无效——吴效科团队发表在《美国医学会杂志》临床试验报告数据再分析

Is acupuncture ineffective in treating infertility associated with polycystic ovary syndrome? A reanalysis of data on the clinical trial by WU Xiaoke's team published on JAMA

吴效科、Stener-Victorin和Legro团队于2017年6月27日在《美国医学会杂志》(JAMA)在线发表了"针刺联合克罗米芬治疗中国妇女多囊卵巢综合征之疗效"的随机临床试验报告,结论是"不支持此类病人使用针刺治疗不孕症"。笔者发现这个试验设计存在严重缺陷、造成试验结果不能导致结论。根据该试验报告及其团队成员近期在其他医学期刊发表的研究数据进行二次分析,发现针刺加克罗米芬、针刺对照加克罗米芬都比单纯的克罗米芬干预有更优异的活产率、排卵率及累计排卵率,统计学意义及临床意义都非常显著。笔者认为该团队的原结论是有待商榷的。

WUXiaoke, Stener-Victorin and Richard Legro＇s team published a randomized clinical trial entitled Effect of acupuncture and elomiphene in Chinese women with polyeystie ovary syndrome： a randomized clinical trial in JAMA on June 27, 2017. Their conclusion is ＂this finding does not support acupuncture as an infertility treatment in such women＂. We found that the trial design had serious flaws and that the results could not lead to the conclusion. Based on the reanalysis for the study data and those published in other medical journals recently from the team, it was found that acupuncture plus clomiphene or control acupuncture plus clomiphene had more excellent live birth rate, ovulation rate and cumulative ovulation rate than clomiphene alone, with statistical and clinical significance. The conclusion of the trial is potentially incorrect.