加味芍药汤治疗溃疡性结肠炎湿热内蕴证32例疗效观察

Clinical effect of Jiawei Shaoyao decoction in treatment of ulcerative colitis with internal retention of damp-heat: an analysis of 32 cases

目的:探讨加味芍药汤治疗溃疡性结肠炎湿热内蕴证的临床疗效,并评价其安全性。方法:将64例溃疡性结肠炎湿热内蕴证患者随机分为对照组和治疗组各32例。对照组予口服美沙拉嗪肠溶片治疗,治疗组在对照组基础上予加味芍药汤治疗,均以4周为1个疗程,治疗1个疗程。比较治疗前后2组患者临床综合疗效、中医证候疗效、结肠镜疗效及安全性指标的变化情况。结果:临床综合疗效总有效率、中医证候疗效总有效率、结肠镜疗效总有效率治疗组分别为93.75%、90.63%、87.50%,对照组分别为78.13%、75.00%、71.88%,组间比较,差异均有统计学意义(P<0.05);2组治疗期间均未出现严重不良反应。结论:加味芍药汤治疗溃疡性结肠炎湿热内蕴证有较好的临床疗效,具有减轻患者症状、保护肠道黏膜的作用,且安全性好。

Objective ： To investigate the clinical effect and safety of Jiawei Shaoyao decoction in the treatment of ulcerative colitis with internal retention of damp - heat. Methods ： A total of 64 patients with ulcerative colitis with internal retention of damp -heat were randomly divided into control group and treatment group,with 32 patients in each group. The patients in the control group were given oral mesalazine enteric - coated tablets, and those in the treatment group were given Jiawei Shaoyao decoction in addition to the treatment in the control group. Each course of treatment was 4 weeks,and both groups were treated for one course. The two groups were compared in terms of overall clinical outcome, outcome of traditional Chinese medicine （ TCM ） syndrome, colonoscopic outcome, and safety indices. Results ： There were significant differences between the treatment group and the control group in the overall response rates for overall clinical outcome, outcome of TCM syndrome, and colonoscopic outcome （93.75/90. 63 %/87.50% vs 78. 13 %/75.00%/71.88 % , P 〈 0.05 ）. No patient experienced serious adverse reaction during treatment. Conclusion：Jiawei Shaoyao decoction has a good clinical effect in the treatment of ulcerative colitis with internal retention of damp - heat and can alleviate clinical symptoms and protect intestinal mucosa with good safety.