急性脑梗死患者血浆纤维蛋白原及D-二聚体水平变化的相关研究

Study on the changes of plasma fibrinogen and D-dimer levels in acute cerebral infarction patients

目的:探讨急性脑梗死患者血浆中纤维蛋白原(FIB)和D-二聚体(D-D)水平的变化。方法:选取2016-02~2016-11于我院神经四科治疗的90例急性脑梗死患者作为观察组,并选取50例健康人群作为对照组,分别检测2组研究者血浆的FIB和D-D水平,同时比较不同严重程度患者的血浆FIB和D-D水平。结果:观察组血浆FIB和D-D水平高于对照组(P<0.05);中度急性脑梗死患者血浆FIB和D-D水平高于轻度急性脑梗死组(P<0.05);重度急性脑梗死患者血浆FIB和D-D水平明显高于轻度患者(P<0.01)。结论:急性脑梗死患者血浆FIB和D-D水平变化对病情判断以及临床治疗有重要指导意义。

Objective: To investigate the changes of plasma fibrinogen( FIB) and D-dimer( D-D) levels in patients with acute cerebral infarction. Methods: 90 patients with acute cerebral infarction treated in our hospital from 2016. 02-2016. 11 were selected as the observation group,and 50 healthy people were selected as the control group. Separately the plasma levels of FIB and D-D in 2 groups were detected,meanwhile the Plasma levels of FIB and D-D in patients were compared with different severity. Results: In the observation group,the plasma FIB and D-D levels were higher than the control group( P < 0. 05); the moderate acute cerebral infarction plasma FIB and D-D levels were higher than those of mild acute cerebral infarction group( P < 0. 05),and the severe acute cerebral infarction and the level of D-D in plasma of patients with FIB was significantly higher than the mild group( P < 0. 01). Conclusion: the changes of plasma FIB and D-D levels in patients with acute cerebral infarction have important guiding significance for the diagnosis and clinical treatment.