HO-1、APN在冠心病患者中的表达

The expression and clinical significance of HO-1 and APN in patients with coronary heart disease

目的:探究血红素氧化酶-1(HO-1)、脂联素(APN)在冠心病患者中的表达及临床意义。方法:随机抽取2015-01~2016-01我院心内科收治的患者60例,其中明确诊断为冠心病的患者30例,设为试验组,包括稳定性心绞痛患者7例、不稳定性心绞痛患者12例,急性心肌梗死患者11例,其余30例非冠心病患者设为对照组,分别测定两组患者血清中的HO-1以及APN水平。结果:试验组患者血清中的HO-1水平明显高于对照组患者(P<0.05),具有统计学差异;试验组患者血清中的APN水平明显低于对照组患者(P<0.05),具有统计学差异,其中急性心肌梗死患者的APN水平最低,与稳定性心绞痛患者以及不稳定性心绞痛患者相比较(P<0.05),具有统计学差异。结论:冠心病患者血清中的HO-1水平升高在冠心病发展的过程中具有重要意义,可作为早期诊断冠心病的参考指标;血清中APN水平与冠心病的发生以及其严重程度具有一定的相关性。

Objective: To explore the heme oxygenase-1( HO-1),adiponectin( APN) expression in patients with coronary heart disease and its clinical significance. Methods: 60 patients were randomly selected from January 2015 to January 2016 in the Department of Cardiology in our hospital,which was diagnosed in 30 cases of coronary heart disease patients as experimental group,including 7 cases of patients with stable angina. 12 cases with unstable angina patients,11 cases of patients with acute myocardial infarction,and 30 cases of non coronary heart disease patients as control group,two groups of patients with serum HO-1 and APN levels were measured.Results: The experimental group in the serum of patients with HO-the 1 level was significantly higher than that in control group,( P < 0. 05); with statistical difference,the serum APN levels in test group were significantly lower than those in control group,( P < 0. 05); with a statistically significant difference between the patients with acute myocardial infarction APN was the lowest,compared with patients with stable angina and unstable angina patients,( P < 0. 05) with statistical difference. Conclusion: the increase of serum HO-1 level in patients with coronary heart disease has important significance in the development of coronary heart disease,can be used as a reference index for early diagnosis of coronary heart disease; serum APN levels and coronary heart disease and its severity has certain relevance.