异种脐血单个核细胞移植对老年小鼠的影响

Study of the Effects of Cord Blood Mononuclear Cells Xenotransplantation upon Aged Mouse

随着我国逐渐步入老龄化社会,老年人整体健康质量的提高亟待解决.而探讨将长寿命物种的干细胞鞘内移植进低寿命物种,移植细胞的存活情况及其对宿主的影响具有重要意义.为此,通过大样本观察鞘内移植人脐血单个核细胞对小鼠自然衰老进程的影响,明确鞘内注射的人脐血单个核细胞可在老年小鼠脑脊液中存活一段时间,并能显著提高老年小鼠的骨密度(P=0.000),且无明显副作用,但其不能提高老年小鼠的心脏每搏量以及改善脑组织端粒长度(皆P>0.05).

With the society stepping into an aging t ime, improving the overall health qual ity of the older is a burning issue. It is signif i-cant to study the survival rate and the effect on the host by injecting the stem cells of long-l ived species into the short-lived species. Therefore, the effects of intrathecal injection human cord blood mononuclear cells upon mouse natural aging process were observed. The data suggests that the intrathecal ly injected human cord blood mononuclear cells can survive for a period of time in mouse cerebrospinal fluid. They can significantly improve the bone density of old mouse with no obvious side effects（P =0. 000） . But they can51 change the cardiac stroke volume and brain cell telomere length of the old mouse（ all P 〉 0. 05 ）.