鼻息肉中促增殖因子表达及相关性被引量：2

A comparative study of growth promoting factors in nasal polyps

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摘要目的探讨胰岛素样生长因子(IGFs)、转化生长因子(TGF-β1)、碱性成纤维细胞生长因子(b FGF)及血管内皮生长因子(VEGF)在鼻息肉发生中的作用。方法 35对鼻息肉和下鼻甲黏膜组织,分别用免疫组化和免疫印迹检测其IGF、TGF-β1、b FGF及VEGF的表达。结果鼻息肉中IGF、TGF-β1、b FGF和VEGF的表达均比下鼻甲对照组明显增加(P<0.05);IGF的表达与TGF-β1、b FGF和VEGF的表达呈正相关(P<0.05)。结论 IGF、TGF-β1、b FGF和VEGF的表达可能与鼻息肉的发生有关,多种细胞因子共同作用导致了鼻息肉的发生与发展。 Objective To research the effect of insulin-like growth factors （IGFs）, transforming growth factor （TGF - beta 1 ）, basic fibroblast growth factor （bFGF） and vascular endothelial growth factor （VEGF） in development of nasal polyps. Methods The expression of IGF, tgf-beta 1, bFGF and VEGF were test by immunohistochemical and Western blot respec： tively within 35 pairs of nasal polyps and inferior nasal eoncha. Results The expression of IGF, tgf-beta 1, bFGF and VEGF were significantly increased in nasal polyps （ P 〈 0.05 ）. The expression of IGF was positively associated with the expression of tgf-beta 1, bFGF and VEGF （ P 〈 0. 05 ）. Conclusion The expression of IGF, tgf-beta 1, bFGF and VEGF may be related to the occurrence of nasal polyps, multiple cytokines＇ combined action contribute to the occurrence and development of nasal polyps.

作者庄坤袁慧钧秦晓威刘晓磊

机构地区哈尔滨医科大学附属第一医院耳鼻咽喉头颈外科

出处《哈尔滨医科大学学报》 CAS 2017年第5期427-429,共3页 Journal of Harbin Medical University

基金黑龙江省卫生厅科研课题(2012-517)

关键词鼻息肉促增殖因子免疫组化免疫印迹 nasal polyps promoting multiplication factor immunohistoehemical Western blot

分类号 R766.3 [医药卫生—耳鼻咽喉科]

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参考文献2

1何宁,梁建平,陈俊,周向阳,韦海明,周祥祯,王涛.IGF-ⅠR在鼻息肉组织中的表达与变应性因素的关系[J].临床耳鼻咽喉头颈外科杂志,2011,25(22):1019-1021. 被引量：3
2范秋虹,顾永平,冯一中,徐永兴.TGF-β1、VEGF表达和微血管密度与结直肠癌侵袭转移的关系[J].苏州大学学报（医学版）,2008,28(4):604-607. 被引量：4

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