摘要
目的探究特发性全面性癫痫(idiopathicgeneralizedepilepsy,IGE)患者的决策冲动行为。方法对39例IGE患者和40例人口学资料匹配的健康人采用延迟折扣任务(delaydiscountingtask,DDT)进行决策冲动性的研究。即被试在经过一段时间延迟的两个不同金额奖赏之间进行选择。结果折扣率(Discountrate)k经过对数转换得到常用对数lg(k)。IGE组lg(k)=-1.75±0.86明显大于HC组lg(k)=-2.21±0.72,差异具有统计学意义(t=2.58,P=0.01);IGE组词语流畅测试(语义)得分[M(P25,P27):16.00(14.00,19.00)分]低于HC组[18.00(16.00,22.75)分],差异具有统计学意义(z=-2.86,P〈0.01);词语流畅测试(语音)得分[M(P25,P75):4.00(3.00,6.00)分]低于HC组[7.00(6.00,10.00)分],差异具有统计学意义(z=-4.26,P〈0.01);IGE组数字广度测试(倒序)得分[M(P25,P75):5.00(5.00,7.00)分]低于HC组[6.00(5.00,8.00)分],差异具有统计学意义(z=-2.48,P=0.01);并且IGE组ig(k)与词语流畅测试(语义)得分(r=0.32,P=0.048)存在显著相关。结论IGE患者在延迟折扣任务中倾向于尽快得到奖赏,表明其决策行为更冲动;1GE存在额叶语言功能和注意功能障碍;并且IGE患者的行为冲动与额叶认知功能有关。
Objective To explore the decision-making impulsivity in patients with idiopathic gener- alized epilepsy. Methods 39 patients with idiopathic generalized epilepsy and 40 healthy controls comple- ted delay discounting task.The participants were demanded to make a series of choices between two different rewards after a delayed period (a smaller sooner reward or a larger longer reward). Results The delay dis- count rate k was transformed to common logarithm lg (k) ,and lg (k)= -1,75-+0.86 in IGE group was more larger than that in HC group lg (k) = -2.21±0.72( t= 2.58 ,P= 0.01 ) .IGE group performed worse than HC group in verbal fluency test-semantic ( M ( Pz5, P75 ) : 16.00 ( 14.00, 19.00) vs 18.00 ( 16.00,22.75 ) , Z = -2.86,P〈0.01 ), verbal fluency test-voice ( M( P25, P75 ) :4.00 ( 3.00, 6.00) vs 7.00 ( 6.00, 10.00), Z= -4.26,P〈0.01) and digital span backward test (M(P25 ,P75 ):5.00(5.00,7.00) vs 6.00(5.00,8.00),Z= -2.48,P=0.01) .In addition,lg (k) had significant correlation with verbal fluency test-semantic (r= 0.32, P=0.048). Conclusion ICE group prefer immediate rewards and show tnore impulsive than HC group indelay discounting task.IGE group has cognitive deficit in frontal lobe language function and attention function. In addition,impulsivity is correlated with frontal lobe function.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2017年第11期983-988,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家重点研发计划项目(2016YFC1300600)
国家自然科学基金项目(91432301,81300944)
关键词
特发性全面性癫痫
延迟折扣
冲动性
决策
Idiopathic generalized epilepsy
Delay discounting
lmpu|sivity
Decision making