稳定期妄想型精神分裂症患者睡眠对记忆巩固的影响及相关性研究

The effects and relevance of sleep on memory consolidation in patients with stable paranoid schizo- phrenla

目的探讨稳定期妄想型精神分裂症患者的记忆功能及睡眠对其记忆巩固的影响。方法将60名稳定期妄想型精神分裂症患者随机分为研究组（n：30）和病例对照组（n=30），募集30名健康者作为健康对照组，使用多导睡眠仪PSG对研究组、健康对照组进行t0h的睡眠监测，采用多维记忆评估量表（multiplememoryassessmentscale，MMAS）中记忆测试工具于被试睡眠前后进行记忆测定，病例对照组患者于白日等长时间前后记忆测定，比较前后记忆功能。结果研究组、病例对照组与健康对照组前测记忆功能比较组问均差异有统计学意义（F（2..18，）=31．40、39．89，均P〈0．01）；研究组与健康对照组后测记忆回忆保持率、再认准确率等组间变量均差异无统计学意义（均P〉0．05），而研究组与病例对照组间汉词回忆保持率[（62．64±9．06）％，（43．00±9．73）％，P〈0．01]、汉词再认准确率[（69．11±11．04）％，（61．78±11．67）％，P〈0．05]及图画回忆保持率[（71．20±14．95）％，（58．72±16．19）％，P〈O．01]、图画再认准确率[（86．89±8．02）％，（78．89±12．63）％，P〈0．01]等变量组问均差异有统计学意义；研究组患者N2期（r=0．377，P〈0．05）、REM（r=0．436，P〈0．05）与汉词后测再认准确率均存在正相关。结论稳定期妄想型精神分裂症患者的记忆功能（听觉汉词词语、图画回忆及再认）总体水平差于健康人，睡眠对精神分裂症患者的记忆巩固有促进作用，而且N2、REM与汉词后测再认准确率均存在正相关。

Objective To explore the memory function and the effects of sleep on memory consoli- dation in patients with stable paranoid schizophrenia. Method Sixty patients with stable paranoid schizo- phrenia were randomly assigned into research group（ n= 30） and control group （n= 30）.30 healthy people were raised as a healthy control group.The polysomnography （PSG） was used for 10 hours of sleep monito- ring in the research group and the healthy control group and the multiple memory assessment scale（MMAS） was used to test the subjects memory before and after the sleep monitoring. Control group performed memory tests in equal length daytime. Pre-test and post-memory measurements were compared. Results The pre- memory test of three groups had significant statistical differences （F=2,87 = 31.40,39.89;P〈0.01） .Both the auditory verbal/picture memory conservation rate and recognition accuracy rate between research group and healthy controls had no statistically significance differences （P〉0.05） .But compared with the control group, auditory verbal memory conservation rate（（62.64±9.06） % vs （43.00±9.73）% ,P〈0.01 ） ,recognition accu- racy rate （ （ 69.11 ±11.04 ） % vs （ 61.78± 11.67 ） %, P〈 0.05 ）, picture memory conservation rate （ （ 71.20 ± 14.95） % vs （ 58.72± 16.19） %, P〈 0.01 ） , recognition accuracy rate （ （ 86.89 ± 8.02 ） % vs （ 78.89 ±12.63） % ,P〈0.01 ） of the research group showed statistical significance differences （P〈0.05）.Both N2 （r= 0.377, P〈0.05 ） and REM （r= 0.436, P〈0.05 ） had positive correlation with recognition accuracy rate of audi- tory verbal memory in research group. Conclusion Stable paranoid schizophrenic patients have poorer memory function（ auditory verbal words memory recall, picture memory recall） than healthy people. Sleep promotes the consolidation of memory in patients with schizophrenia. Both N2 and REM of patients with stable paranoid schizophrenic have positive correlation with recognition accuracy rate of auditory verbal memory.