泮托拉唑与吗丁啉和铝碳酸镁三联治疗慢性胃炎的临床疗效

Effect of pantoprazole,domperidone and hydrotalcite triple therapy to improve symptoms in patients with chronic gastritis

目的探讨泮托拉唑、吗丁啉、铝碳酸镁三联治疗慢性胃炎的临床疗效。方法选择2013年7月~2015年7月在我院接受治疗的慢性胃炎病患者126例,按照完全随机化法分为观察组和对照组各63例。观察组采用泮托拉唑、吗丁啉、铝碳酸镁三联进行治疗,对照组采用泮托拉唑与铝碳酸镁治疗。对比两组治疗效果、不良反应以及相关症状缓解时间。结果观察组治疗的显效率、总有效率均显著高于对照组(P<0.05);观察组症状消失率较对照组高,而观察组上腹疼痛、上腹不适以及头晕、恶心呕吐、腹胀、嗳气等不良反应较对照组低,并且观察组烧灼反酸、胸骨后疼痛以及咽部异物感等症状缓解或消失时间均较对照组更低,差异均有统计学意义(各P<0.05)。结论泮托拉唑、吗丁啉、铝碳酸镁三联疗法对慢性胃炎具有显著的治疗效果,可缓解临床症状,降低相关症状消失时间,具有较高的临床应用价值。

Objective To evaluate the clinical efficacy of pantoprazole, domperidone and hydrotalcite triple therapy on chronic gastritis patients. Methods 126 patients with chronic gastritis disease from July 2013 to July 2015 in our hospital were randomly divided into the observation group （63 cases） and the control group （63 cases）. The observation group was treated with pantoprazole, domperidone, hydrotalcite triple treatment. The control group was treated with pantoprazole and aluminum magnesium carbonate treatment. The treatment effect, adverse reaction and symptom remis- sion time were observed. Results The effective rate and total effective rate of the observation group were 57.14% （36/ 63） and 95.24% （60/63）, respectively, which were significantly higher than that of control group （36.51% and 80.95%）. The symptom disappearance rate in the observation group was significantly higher than that of the control group （P〈0.05）. The epigastric pain, epigastric discomfort, dizziness, nausea and vomiting, abdominal distention, belching and other adverse reaction disease patient ratio in the observation group were significantly lower than that of the control group （P〈0.05）. T The burning acid reflux, retrosternal pain and feeling of pharynx ministry eyewinker symp- toms slow solution or disappearance time of observation group were significantly lower than those of the control group （P〈0.05）. Conclusion Pantoprazole, domperidone, hydrotalcite triple therapy on chronic gastritis disease has a very sig nificant therapeutic effect. It can effectively alleviate the clinical symptoms and reduce the disappearance time of symptoms.