安宫牛黄丸辅助病毒唑对小儿急性重症病毒性肺炎血清降钙素原及免疫功能的影响

Study on Effect of Angong Niuhuang Pill Combined with Ribavirin In Treatment of Acute Severe Viral Pneumonia in Children in Serum Calcitonin and Immune Function

目的:探讨安宫牛黄丸辅助病毒唑对小儿急性重症病毒性肺炎血清降钙素原及免疫功能的影响。方法:选取2015年2月—2016年8月海南省海口市妇幼保健院收治的符合纳入标准的急性重症病毒性肺炎患儿88例,按随机数字表法分组,分别44例,对照组予以病毒唑常规治疗治疗,研究组予以安宫牛黄丸辅助病毒唑治疗,共治疗7 d,采血测定免疫功能、炎症因子及基质金属蛋白酶等指标,同时对比临床疗效及安全性。结果:与治疗前数据对比,两组治疗后Ig M、Ig G、Ig A含量升高,治疗后CD3、CD4、CD8、CD4/CD8含量升高,治疗后血清hs-CRP、PCT、TNF-α含量降低,IL-2含量升高,治疗后血清MMP9、TIMP1含量降低,差异具有统计学意义(P<0.05);与对照组数据对比,研究组治疗后Ig M、Ig G、Ig A含量较高,治疗后CD3、CD4、CD8、CD4/CD8含量较高,治疗后血清hs-CRP、PCT、TNF-α含量较低,IL-2含量较高,治疗后血清MMP9、TIMP1含量较低,差异具有统计学意义(P<0.05);对照组有效率72.73%低于研究组有效率90.91%,差异具有统计学意义(P<0.05)。结论:安宫牛黄丸辅助病毒唑对小儿急性重症病毒性肺炎疗效确切,能显著降低降钙素原,提高免疫功能,安全性高。

Objective： To investigate the effect of Angong Niuhuang Pill combined with ribavirin in the treatment of acute severe viral pneumonia in children in serum Calcitonin and immune function. Methods： A total of 88 cases of acute severe viral pneumonia in children from maternal and child health care hospital of Haikou February 2015 to August 2016 were selected and randomly divided into 2 groups,44 cases in each. The control group received ribavirin treatment and the treatment group additionally received Angong Niuhuang Pills and 2 groups were treated for 7 days. Immune function,inflammatory factors and matrix metalloproteinases and other indicators,at the same time,we compared the clinical efficacy and safety were compared before and after treatment. Results： Compared with those before treatment,levels of Ig M,Ig G and Ig A in 2 groups increased,levels of CD3＋,CD4＋,CD8＋and CD4＋/CD8＋increased. Levels of serum hs-CRP,PCT and TNF-α content decreased. The serum MMP9 and IL-2 contents increased and TIMP1 decreased after treatment. The difference was statistically significant（ P〈0. 05）,and we compared with the control group,levels of Ig M,Ig G and Ig A in the treatment group were higher. Levels of CD3＋,CD4＋,CD8＋and CD4＋/CD8＋were higher and levels of serum hs-CRP,PCT and TNF-α contents were lower,levels of IL-2 content were high,and levels of serum MMP9 and TIMP1 contents were lower. The difference was statistically significant（ P〈0. 05） and the total effective rate in control group（ 72. 73%） was lower than the treatment group＇s（ 90. 91%） and the difference was statistically significant（ P〈0. 05）. Conclusion： Angong Niuhuang Pills combined with ribavirin in the treatment of acute viral pneumonia in children was effective and it can significantly reduce the procalcitonin and improve immune function with high safety.