活血通腑类方剂及有效组分防治腹腔粘连研究进展

Mechanism of Classical Prescriptions of Invigorating Blood and Dredging the Bowels and Effective Component Preventing Progression of Peritoneal Adhesion

由西医、中医角度总结腹腔粘连(peritoneal adhesion,PA)的发病机制,对活血通腑类方剂防治腹腔粘连(PA)进展的机制进行总结。通过对国内外文献的整理发现防治腹腔粘连的活血通腑类方剂包括:活血通腑方、丹参厚朴合剂、理气活血汤等,基于临床疗效和药理机制两个层面归纳梳理其治疗腹腔粘连的研究进展。并对近八年活血通腑类中药报道的有效组分进行概述。今后基础研究可以从临床中药复方的主要组成药物的关键组分着手,结合体内、外的机制研究,以期从更深层次、更全面地阐明活血通腑类方治疗腹腔粘连的相关机制;临床研究,应根据实际情况选择确切阳性药物为对照组,进行以双盲、随机、对照为原则的大样本、多中心的临床试验,规范中医药治疗术后腹腔粘连的临床试验研究更为规范、可靠、全面。

This paper summarized the research progress of prescriptions of invigorate blood and dredge the bowels in treating peritoneal adhesion（ PA） from Western medicine and TCM. These prescriptions include Invigorate Blood and Dredge the Bowels prescription,Salvia miltiorrhiza bark mixture,Liqi Huoxue decoction and so on were found through the collation of the domestic and foreign literature based on clinical efficacy and pharmacological mechanism. Moreover,the effective components of prescriptions of invigorate blood and dredge the bowels in the last eight years reported were summarized. In the future,basic research can be made from the key components of the traditional Chinese medicine compound,combined with the mechanism of in vivo and in vitro in order to elucidate the related mechanism of the treatment of peritoneal adhesion with the method of invigorate blood and dredge the bowels. Clinical study should be paid attention to the actual situation to choose the exact positive drugs as the control group. In addition,multicenter,double blind,randomized,clinical trials in treatment of postoperative abdominal adhesion were needed to remains to be.