淋巴瘤患者院内感染病原菌分布的Meta分析

Pathogen distribution of the nosocomial infection in lymphoma patients:a Meta analysis

目的系统评价淋巴瘤患者院内感染病原菌分布情况。方法全面系统检索维普(VIP)、万方数据库、中国知网(CNKI)、中国生物医学文献服务系统(CBM)及Pub Med。搜索关键字包括淋巴瘤、院内感染、病原体,并追索已纳入文献的参考文献,对文献进行评价与资料提取,使用RStudio软件进行meta分析。结果研究显示淋巴瘤患者的医院感染率为22%[95%CI(18%,26%)],其中革兰氏阴性细菌感染率为45%[95%CI(36%,57%)],革兰氏阳性细菌感染率为28%[95%CI(24%,34%)],真菌感染率为25%[95%CI(18%,36%)],其他感染2%。院内感染部位以呼吸道为主,革兰氏阴性细菌是主要病原体,革兰氏阳性细菌和真菌感染的比例相当。革兰氏阴性菌中,以肺炎克雷伯菌、大肠埃希菌以及铜绿假单胞菌为主要致病菌,革兰氏阳性菌中,以金黄色葡萄球菌、表皮葡萄球菌为主要致病菌,而在真菌中,白色念珠菌占绝大比例。结论革兰氏阴性细菌是淋巴瘤患者院内感染最常见的病原菌,1/4感染由真菌引起。

Objective To know more about pathogen distribution of the nosocomial infection in lymphoma patients. Methods Related literature was retrieved from databases including VIP,Wangfang, CNKI,CBM and PubMed,using ＂lymphoma＂, ＂nosocomial infection＂ and ＂pathogen＂as the key words. References includ- ed were traced,evaluated and the related information was extracted. A meta-analysis was conducted using RStudio. Reaults Tne study showed that lymphoma pa- tients with hospital infection rate was 22% [95% CI（ 18% ,26% ） ] ,grmn-negative bacteria infection rate was 45% I95% CI（36% ,57% ） ,gram-positive bacteria in- fection rate was 28% [95% CI（24% ,34% ） ] ,funga] infection rate was 25% [95% CI（ 18% ,36% ） ]. The respiratory tract infection was the most conanon nosocomial infetion. Klebsiella pneumouiae,eseheriehia eoli and pseudomonas aeruginosa were the major contril3uting gram-negative haeteria,staphylococcus, cus aureus and staph- ylococcus epidermidis were the major pathegens of gram-positive bacteria infection,whereas candida albieans was the major contributing fungi. Conclusion Gram- negative bacteria is the major pathogen of nosocnmial infection in lymphonm patients. A quarter of infection was caused by fungi.