针灸对克罗恩病肠黏膜屏障的保护作用

The Protection of Acupuncture & Moxibustion on Intestinal Mucosa Barrier of Crohn's Disease

克罗恩病是临床常见难治病,其病因及发病机制仍尚未完全阐明。肠黏膜屏障是机体屏障系统的一个重要组成部分,对防御病菌侵入及维持肠道免疫稳态起重要作用,而肠黏膜屏障功能受损是感染和免疫因素参与CD发病,启动CD肠道炎症反应的关键环节。中医针灸在维持CD肠黏膜屏障结构的完整和正常功能的发挥方面具有一定的特色和优势,文章就针灸对CD肠黏膜屏障的保护作用机制作一综述。

To date, the etiology and pathogenesis of Crohn~ disease （CD） has not been fully elucidated. As an important de- fensive line for human body against the environment, intestinal mueosa is able to protect the homeostasis of gut bacteria, alleviate the intestinal inflammatory and immune response. It is evident that the dysfunction of intestinal mucosa barriers plays a crucial role in CD initiation and development. In maintaining the structure and function of intestinal mucosa barrier, acupuncture and moxibustion possesses the definite features and advantages to some extent. In this article, we outlined the protection of acupunc- ture and moxibustion on intestinal mucosa barrier of Crohn＇s disease.