从微生物转化的方向解决重楼资源不足的展望

Application of Microbial Transformation to Solve the Shortage of Rhizoma Paridis

中药重楼具有显著的药理活性,临床应用广泛,是云南白药、宫血宁等多种中成药的主要原料之一,但重楼生长周期长、生长速度慢,引种驯化没有取得突破性在进展,价格居高不下,道地野生资源破坏严重,重楼资源面临枯竭在危险。大量研究资料证明植物内生菌具有强大的代谢功能,能够产生与宿主相同或相似的活性成分,可以通过利用微生物发酵培养生产活性化合物的方法来解决重楼资源不足的难题。

Rhizoma Paridis has significant pharmacological activity and is widely used in clinical practice. It is one of the main materials of Yunnan Baiyao, Gongxuening and other proprietary Chinese medicines. However, Rhizoma Paridis has long growth cy- cle, increasingly expensive, wild resources was seriously damaged, Rhizoma Paridis are facing depletion in danger. A lot of re- search show that plant endophytic bacteria have strong metabolic function, can produce the same or similar active ingredients as the host, the microbial transformation can be used to solve the problem of lack of Rhizoma Paridis.