摘要
为了比较不同含量冰片和薄荷油及不同含量氮酮对接骨乳膏体外透皮吸收的影响。以SD大鼠的背部皮肤为透皮实验模型,每隔2 h,以分光光度法测定接收池中总甾酮含量。结果表明:随着冰片、薄荷脑及氮酮含量的增加,单位时间通过单位面积皮肤的药物量逐渐增加。添加0.36 g冰片和0.04 g薄荷脑的接骨乳膏的透皮吸收能力稍强于添加4%氮酮接骨乳膏的透皮吸收能力。选择0.36 g冰片,0.04 g薄荷油作为促透皮吸收剂为较好的选择。
To comparison transdermal absorption between different composite ratio of Azone and borneol-menthol. Back skin of SD rats were used as the transdermal experiment material. After transdermal absorption,the contents of total phytosterone in the reception tank were measured at regular intervals by spectrophotometry every 2 h. Azone and borneol-Menthol in different concentration can significantly increase it＇s permeability,which the best concentration was 0. 36 g borneol and 0. 04 g Menthol not 4% Azone. The optimal dose proportion is 0. 36 g borneol and 0. 04 g menthol.
出处
《山地农业生物学报》
2017年第5期87-90,共4页
Journal of Mountain Agriculture and Biology
基金
教育部新世纪人才支持计划(No.[2014]95)
贵州省优秀青年科技人才培养对象专项(No.[2014]34号)
关键词
接骨乳膏
透皮吸收
新药研究
冰片
薄荷脑
Jiegu cream
transderm delivery
new medicines study
borneol
menthol
