角膜屈光手术后角膜生物力学参数变化的研究

ANALYSIS OF BIOMECHANICAL PARAMETERS ABOUT MODERATE MYOPIA PATIENTS'REFRACTIVE SURGERY

目的:探讨中低度近视病人屈光手术后角膜生物力学相关参数的变化,从角膜生物力学角度对屈光手术的安全性及有效性进行研究。方法:选择中低度近视病人80例,进行Corvis ST检查,对手术前及术后1wk病人的眼压(intraocular pressure,IOP)及角膜生物力学主要参数包括中央角膜厚度(central covneal thickness,CCT)、第一压平时间(the first applanation time,A-time 1)及最大形变幅度(deformation amplitude,DA)等进行分析。结果:屈光手术前后IOP值分别为19.113±3.494mm Hg和13.385±3.011mm Hg,CCT值分别为576.137±36.894μm和(478.201±40.543)μm,A-time 1值分别为7.523±0.379ms和7.465±0.093ms,差异均有统计学意义(P<0.05);DA值分别为0.948±0.071mm和0.974±0.107mm,差异无统计学意义(P>0.05)。结论:中低度近视病人角膜屈光手术后角膜生物力学参数中IOP、CCT及A-time 1有变化,DA值无变化。

Objective： To study the efficacy and safety of refractive surgeryfrom the perspective of corneal biomechanical,we do a research to discuss the change of corneal biomechanical parameters on patients with moderate myopia after refractive surgery. Methods： In this retrospective study,we choose80 cases of moderate myopia patients to examine intraocular pressure（ IOP） and biomechanical parameters（ central corneal thickness,CCT; the first applanation time,A-time 1; deformation amplitude,DA）before and after refractive surgery. Results： Before and after refractive surgery,the mean value of IOP respectively is 19.113 ± 3.494 mm Hg and 13.385 ± 3.011 mm Hg,CCT is 576.137 ± 36.894 μm and478.201±40.543μm,A-time 1 is 7.523±0.379 ms and 7.465±0.093 ms and DA is 0.948±0.071 mm and0.974 ±0.107 mm.So we can draw a conclusion that there are a significantly difference in the mean value of IOP,CCT and A-time 1 between pro-operation and post-operation（ P 〉0.05）,but no difference in the mean value of DA（ P〈0.05）.Conclusion： The corneal refractive surgery on patients with moderatemyopiahas changed the value of IOP,CCT and A-time 1,but not changed DA.