艾灸关元穴对慢性肾小球肾炎患者微炎症状态及肾功能的影响

Effects of Moxibustion at Guanyuan Acupoint on Microinflammation and Renal Function in Patients with Chronic Glomerulonephritis

目的:观察艾灸关元穴对慢性肾小球肾炎(chronic glomerulonephritis,CGN)患者微炎症状态及肾功能的影响。方法:纳入CGN患者82例,按随机数字表将患者分为艾灸组42例和对照组40例。对照组患者给予慢性肾脏病的常规治疗,艾灸组患者在常规治疗基础上加用艾灸关元穴治疗,两组疗程均为8周。比较两组患者的临床疗效,于治疗前后检测两组患者的24 h尿蛋白定量、高敏C反应蛋白(plasma Creactive protein,p-CRP)水平及肾功能指标[包括血清尿素氮(BUN)、血清肌酐(SCr)、肾小球滤过率(GFR)]。结果:治疗后,艾灸组与对照组的临床总有效率分别为76.2%和45.0%,艾灸组的疗效明显优于对照组(P<0.05)。治疗后,两组患者的24 h尿蛋白定量、p-CRP水平均显著降低(P<0.05),且艾灸组患者的24 h尿蛋白定量、p-CRP水平明显低于对照组(P<0.05);对照组患者的SCr水平显著降低(P<0.05),艾灸组患者的BUN与SCr水平均显著降低(P<0.05,P<0.01)、GFR水平显著升高(P<0.01),且艾灸组患者的BUN与SCr水平明显低于对照组(P<0.05,P<0.01)、GFR水平显著高于对照组(P<0.01)。结论:艾灸关元穴对CGN患者具有明显的抑制微炎症作用,能有效缓解肾小球毛细血管损伤,降低蛋白渗出,从而改善肾功能,具有一定的临床推广价值。

Objective ： To observe the effects of moxibustion at Guanyuan （CV4） acupoint on the microinflammation and renal function in patients with chronic glomcrulonephritis （CGN）. Methods： A total of 82 patients with CGN were enrolled and randomly divided into the moxibustion group （ n = 42） and control group （ n = 40） by random number table. The patients in the control group were treated with routine therapy of chronic kidney disease, and the patients in the moxibusti0n group were treated with moxibustion at Guanyuan （CV4） acupoint based on the routine therapy, with a course of 8 weeks. The clinical efficacy was compared, and the 24 h urine protein quantitation and the levels of plasma C-reactive protein （p-CRP） and renal function indexes including blood urea nitrogen （ BUN）, serum creatininc （SCr） and glomerular filtration rate （GFR） were detected before and after treatment. Results： After treatment, the clinical total effective rates of the moxibustion group and control group were 76.2% and 45.0% respectively, and the efficacy of the moxibustion group was obviously better than that of the control group （P 〈0.05）. After treatment, the 24 h urine protein quantitafion and the level of p-CRP were significantly decreased in both groups （P 〈0.05 ）, and the 24 h urine protein quantitation and the level of p-CRP of the moxibustion group were obviously lower than those of the control group （ P 〈 0.05 ）. After treatment, the level of SCr of the control group was markedly decreased （ P 〈 0.05 ）, and the levels of BUN and SCr of the moxibustion group were significantly decreased （ P 〈 0.05 ,P 〈 0.01 ） and the GFR level was significantly increased （P 〈 0.01 ） ; the levels of BUN and SCr of the moxibustion group were obviously lower than those of the control group （ P 〈 0.05,P 〈 0.01 ）, and the GFR level of the moxibustion group was significantly higher than that of the control group （ P 〈 0.01 ）. Conclusion ： Moxibustion at Cuanyuan （ CV4 ） acupoint can obviously inhibit the microinflammation in patients with chronic glomerulonephritis, effectively relieve the glomerular capillary injury, reduce the urinary protein exudation and thus improve the renal function, which shows a certain clinical promotion value.