阿托伐他汀对急性缺血性卒中颈动脉粥样硬化斑块的疗效

The Effect of Atorvastatin on Carotid Atherosclerotic Plaques in Patients With Acute Ischemic Stroke

目的探究阿托伐他汀治疗急性缺血性卒中患者颈动脉粥样硬化斑块的应用效果。方法选取我院收治的急性缺血性卒中伴颈动脉粥样硬化斑块患者96例作为研究对象。采用抽签法,将其分为实验组与参照组,每组各48例。参照组采用常规疗法,实验组在此基础上,加用阿伐他汀治疗。结果治疗后,实验组患者的CIMT为(0.714±0.020)mm,斑块面积为(0.805±0.085)cm2;参照组分别为(0.852±0.028)mm,斑块面积为(0.956±0.091)cm2;实验组的TC为(4.47±0.34)mmol/L,TG为(1.43±0.36)mmol/L,LDL-C为(2.53±0.44)mmol/L,HDL-C为(1.49±0.23)mmol/L;参照组相对应的指标依次为(5.92±0.40)mmol/L,(1.78±0.41)mmol/L,(3.94±0.41)mmol/L,(1.25±0.19)mmol/L;实验组各指标数据均优于参照组,两组比较,差异具有统计学意义(P<0.05)。结论应用阿托伐他汀治疗急性缺血性卒中患者的颈动脉粥样硬化斑块效果显著。

Objective To explore the effect of atorvastatin in the treatment of carotid atherosclerotic plaques in patients with acute ischemic stroke. Methods 96 cases of acute ischemic stroke with carotid atherosclerotic plaques were selected as the study objects, and they were divided into experimental group and reference group by drawing lots, 48 cases in each group. The reference group was treated with conventional therapy, and the experimental group was treated with atorvastatin on this basis. Results After treatment, the CIMT in the experimental group was （0.714 ±0.020） mm, and the plaque area was （0.805±0.085） cm2. In the reference group, the CIMT was （0.852±0.028） mm, and the plaque area was （0.956±0.091） cm2. The TC of the experimental group was （4.47±0.34） mmol/L, TG was （1.43±0.36） mmol/L, LDL-C was （2.53~0.44） mmol/L, and HDL-C was （1.49±0.23） mmol/L. The corresponding indexes of the reference group were （5.92±0.40） mmol/L, （1.78±0.41）mmool/L, （3.94±0.41） mmol/L, and （1.25±0.19） mmol/L; The data of each index in the experimental group were better than those in the reference group, and the difference between the two groups was statistically significant （P 〈 0.05）. Conclusion The effect of atorvastatin treatment of acute ischemic stroke patients with carotid atherosclerosis plaque is significant.