摘要
金黄色葡萄球菌生物被膜的形成是一个多基因和多因子共同调控的过程。葡萄球菌属辅助调节子SarA是金黄色葡萄球菌主要的毒力基因表达调控系统,能直接或间接调控多种生物被膜形成相关基因的表达。本文对SarA的结构及其调控生物被膜形成的机制作一综述,以期为深入研究金黄色葡萄球菌的致病机理和开发新的抗生物膜感染策略提供参考。
Staphylococcus aureus biofilm mode of growth is coherently regulated by multiple genes and factors.Staphylococcal accessory regulator SarA is one of the major regulatory systems which mediate virulence genesexpression in S. aureus. Several biofilm- associated genes expression is controled by SarA either in a direct orindirect way. This article conducted a general review regarding the structures of SarA and its regulatorymechnisams on biofilm formation by Staphylococcus aureus. These findings provide an important reference for thepathogenesis of S.aureus and the development of new strategies applied to eradicate biofilm-associated infections.
出处
《中国兽药杂志》
北大核心
2017年第12期62-67,共6页
Chinese Journal of Veterinary Drug
基金
吉林省教育厅"十三五"科学技术研究项目(吉教科合字[2016]第194号)
