中性粒细胞/淋巴细胞比值与无症状性颈动脉狭窄斑块稳定性的相关性研究

Correlation between Neutrophil/Lymphocyte Ratioand Asymptomatic Carotid Artery Stenosis

目的:研究中性粒细胞/淋巴细胞比值(Neutrophil lymphocyte ratio,NLR)与无症状颈动脉狭窄(asymptomatic carotid artery stenosis,aCAS)粥样斑块稳定性的相关性。方法:收集我院门诊及住院部2015年10月-2017年1月被诊断为无症状性颈动脉狭窄的患者共122例,通过颈部血管超声将颈动脉粥样斑块分为稳定组、不稳定组,并分别比较两组中性粒细胞绝对值、淋巴细胞绝对值、NLR水平,同时分析NLR与粥样斑块所致无症状性颈动脉狭窄的斑块稳定性的关系。结果:两组比较,稳定组、不稳定组淋巴细胞值分别为(2.19±0.51)×10~9/L、(1.87±0.56)×10~9/L,NLR分别为1.44±0.57、2.56±0.78,两组比较有统计学意义(P=0.011、0.008)。有序多分类回归分析显示NLR是不稳定粥样斑块所致无症状性颈动脉狭窄的独立危险因素(OR=5.548,95%CI:2.367~12.378,P<0.001)。结论:NLR与无症状性颈动脉狭窄斑块稳定性具有相关性。

Objective：To study the association of neutrophil/lymphocyte ratio（NLR）with plaque morphologyin patients with asymptomatic carotid artery stenosis（aSCA）.Methods：122 patients with asymptomatic carotid artery stenosis detected by vascular ultrasoundin our hospital from October 2015 to January 2017 were divided into stable group and unstable group,and then compare two groups of absolute value of neutrophil and absolute value of lymphocyte.Their NLR was calculated and compared.Risk factors for asymptomatic Carotid Artery Stenosis were analyzed byordinal logistic regression analysis.Results：Two groups of comparisons,stable group,unstable group lymphocyte value were（2.19±0.51）×10^9/L,（1.87±0.56）×10^9/L,NLR 1.44±0.57,2.56±0.78,respectively,comparing the two groups was statistically significant（P=0.011,0.008）.Orderly,classification and regression analysis suggested that NLR was asymptomatic carotid stenosis independent risk factor for the development of unstable plaques（OR=5.548,95%CI：2.367-12.378,P〈0.001）.Conclusion：NLR is correlated with the risk of asymptomatic Carotid Artery Stenosis.