脑动静脉畸形治疗前后血浆血管内皮生长因子水平变化

The changes of plasma VEGFin cerebral arteriovenous malformations

目的检测脑动静脉畸形(AVM)患者治疗前后的血浆血管内皮生长因子(VEGF)水平,进一步研究VEGF在AVM中的病理生理作用。方法纳入17例AVM患者,分别取切除手术前、手术后24 h和手术后30 d的血液样品。22例腰椎椎板切除术患者的血液样品作为对照。ELISA法检测血浆VEGF水平。结果与对照组相比,AVM组的血浆VEGF极显著下降(P<0.01),AVM手术切除24 h后继续显著下降(P<0.05),而AVM切除手术后30 d持续上升接近至对照组水平(P>0.05)。结论血管异常在AVM中发挥重要病理生理作用,且VEGF的代谢异常参与AVM的病变进程。

Objective Todetectthe level of plasma VEGF before and after treatment of arteriovenous mal- formationpatients, and the pathophysiological role of VEGF in arteriovenous malformationpatientswas also studied. Methods The blood samples of 17 arteriovenous malformation patients were collected according to the following three groups： group before operation （AVM）, group 24 hours after operation （AVM24h） and group 30 days after operation （AVM30d）. As a control （Con）, 22 blood samples were collected from lumbar laminectomypatients. The level of plasma VEGF was determined by ELISA assay. Results Compared with the control group, the plasma VEGF was significantly decreased in AVM group and AVM24h group （P 〈 0.05） , while the plasma VEGF in AVM30d groupwas similarto that of the control group. Conclusions Abnormal blood vessel plays an important pathophysiological role in cerebral arteriovenous malformation, and the metabolism of VEGF is involved in the pro- cess of arteriovenous malformation.