炎性因子及外周血指标与子宫内膜癌诊治及预后相关性研究进展

Research Progress of the Relationship of Inflammatory Factors and Peripheral Blood Indexes with the Diagnosis,Treatment and Prognosis of Endometrial Carcinoma

子宫内膜癌(EC)是在世界范围内发病率较高的妇科恶性肿瘤之一。近年来,人们认识到,癌症患者的诊断及治疗并不完全由癌症的特征决定,而体循环和肿瘤微环境中与肿瘤相关的各种指标也可能是癌症发生和进展的关键因素。其中炎性因子、中性粒细胞、淋巴细胞、血小板及其之间的比值是简单、容易获取且较稳定的临床指标,这些指标已在多种癌症中得到广泛研究。炎性因子和外周血相关指标与EC的发生、发展具有相关性,联合运用相关指标有利于EC的早期诊断及治疗,如何联用炎性因子和外周血相关指标并提高诊断EC的敏感性和特异性是未来研究的重点。

Endometrial carcinoma （EC） is one of the gynecological malignant tumors of high incidence worldwide. In recent years, it＇s realized that the diagnosis and treatment of cancer patients is not entirely determined by the characteristics of cancer, and various indexes in tumor related systemic circulation and microenvironment may also be key factors in the progression of cancer. Among them, inflammatory factors, neutrophils, lymphocytes, platelets and their ratio are simple, easy to obtain and stable clinical indicators, which have been widely studied in a variety of cancers. There is a correlation between the development of relevant indicators of inflammation and peripheral blood and EC, the combination of which is helpful for the early diagnosis and treatment for EC, and how to combine the related indicators of peripheral blood and inflammatory cytokines to improve the sensitivity and specificity of diagnosis of EC is the focus of the future research.