血清降钙素原及CRP在慢性阻塞性肺疾病急性加重期诊治中的作用

Application of Serum Procalcitonin and CRP in Diagnosis and Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是世界范围内导致残疾和死亡的主要原因之一。COPD不仅是一种呼吸道炎症疾病,也是一种伴许多肺外表现的全身性慢性炎症。在COPD急性加重期(AECOPD)滥用抗生素是临床工作中的一个重要难题,从而导致治疗费用增加及超级细菌的产生。降钙素原和C反应蛋白是重要的炎症标志物,在早期诊断AECOPD是否存在细菌感染方面具有很高的特异性和敏感性,并对其指导抗菌药物使用具有重要的临床意义。

Chronic obstructive pulmonary disease （COPD） is one of the leading causes of disability and death world-wide. COPD is not only a respiratory inflammatory condition, but also a mild chronic systemic inflammation accompanied by many extrapulmonary manifestations. In patients with acute exacerbation of COPD （ AECOPD）, there is excessive use of antimierobial drugs, which is a serious problem in clinical practice, resulting in increased treatment costs and the production of super bacteria. Procalcitonin and C-reactive protein are important inflammatory markers, which have high specificity and sensitivity to early diagnosis of bacterial infection, and has great clinical significance to guide the antimicrobial drug use.