猪圆环病毒2型综合免疫及母源抗体评估研究

Evaluation of PCV-2 Comprehensive Immune and Maternal Antibodies in Swine

猪圆环病毒2型(PCV-2)参与引起的疾病症候群较为复杂,疫苗免疫效果受多种因素的影响。目前,疫苗的实际免疫效果及其对其他疫苗免疫效果的影响尚不十分清楚。针对这一问题,根据PCV-2病原和WH疫苗株特点,项目组设计了1组母猪、4组仔猪的免疫试验,并持续监测了免疫抗体及仔猪母源抗体变化情况,同时评估PCV-2免疫对其他疫苗(猪瘟、高致病性猪繁殖与呼吸综合征和猪O型口蹄疫)免疫效果的影响。结果显示,仔猪一次性免疫,不能达到理想的免疫效果,间隔2周~3周加强免疫,效果较好,保护抗体可持续到105日龄以上。母猪配种前和产仔前两次免疫,至仔猪断奶后,母猪抗体较高,所产仔猪,28日龄母源抗体较高。PCV-2疫苗免疫不影响上述3种疫苗的免疫效果。

The porcine circovirus type-2 （PCV-2） participates in the cause of disease syndromes which are very complicated,vaccine immunization effect is affected by various factors.Now,a vaccine that would produce actual results or influence other vaccine immune effects is not yet clear.In order to solve this problem, we designed the tests consisted of three sows and four treatment groups of piglets based on the characteristics of the vaccine strain WH.The monitoring of immune antibody and maternal antibody changes is helpful to the evaluation of PCV-2 vaccine and immune effects of other vaccines （classical swine fever,highly pathogenic porcine reproductive and respiratory syndrome and type-O foot-and-mouth disease）. The results showed that the piglets with one immunization cannot achieve the ideal immune effect, while effects of interval of 2 to 3 weeks to strengthen immunity were well, and protective antibody sustainability is more than 105 days.Twice immunization to sows before mating and birthing may keep higher maternal antibody levels in piglets after weaning when the age of 28 days.These results indicated that PCV-2 vaccine could not influence the immune effects of other three types of vaccines.