苦参止痢颗粒的药效作用研究

Study on Pharmacodynamics of Radix Sophorae Flavescentis Granule

通过小鼠胃肠蠕动试验、小鼠腹泻试验、抗炎试验和镇痛试验,考察苦参止痢颗粒的药效作用。结果表明,与空白对照组相比,苦参止痢颗粒可显著降低蓖麻油所致小鼠的腹泻次数(P<0.01),对正常小鼠胃排空作用有显著的抑制作用(P<0.01),可显著降低二甲苯所致小鼠耳廓的肿胀率(P<0.01),显著提高小鼠耐热痛阈值(P<0.01)。说明苦参止痢颗粒具有止泻、调节胃肠蠕动、抗炎、镇痛等作用。

In order to understand the pharmacodynamic action of Radix Sophorae Flavescentis granule through the mouse gastrointestinal peristalsis test, the mouse diarrhea test, the anti-inflammatory test and the analgesic test, the pharmacodynamic action of Radix Sophorae Flavescentis granule was studied.The results showed that compared with the blank control group, Radix Sophorae Flavescentis granule could significantly reduce the number of diarrhea in mice induced by castor oil （P〈0.01） ,there was a significant inhibitory effect on gastric emptying in normal mice （P〈0.01）,the swelling rate of mouse auricles induced by xylene was significantly decreased （P〈0.01）,and significantly increase the threshold of heat tolerance pain in mice （P 〈0.01）.Radix Sophorae Flavescentis granule has the effect of relieving diarrhea,regulating gastrointestinal peristalsis, resisting inflammation and relieving pain.