lncRNA在器官纤维化疾病中的研究进展

Progress on lncRNAs in Organ Fibrosis

器官纤维化是多种因素引起的器官急性或慢性的病理变化,严重影响人类健康。长链非编码RNA(long noncoding RNA,lncRNA)是一类转录本长度超过200核苷酸非蛋白编码RNA,越来越多证据表明可通过染色质修饰、转录水平、转录后水平等多种调控途径参与多种疾病的发生发展。lncRNA参与调控纤维化多种生物学过程,有望成为器官纤维化诊断和预后分子标志物及药物作用新靶点。论文就lncRNA来源、作用机制及在器官纤维化中的最新研究进展做一综述,以期为器官纤维化的临床诊断和以lncRNA为靶点开发药物治疗器官纤维提供参考。

Organ fibrosis is acute or chronic pathological lesions caused by various of factors, which seriously affects human health.long noncoding RNAs are non-protein coding transcripts longer than 200 nucleotides. Increasing evidence revealed that lncRNAs have key functions in regulating diverse disease processeses, such as chromatin modification,transcription,post-transcription.lncRNAs are involved in the regulation of fibrosis processes, which are expected to become molecular markers of the organ fibrosis diagnosis, prognosis and drug new targets.This article reviewed progress in lncRNAs source, mechanism of action and the latest research on organ fibrosis for providing insights into the clinical diagnosis and lncRNAs as a drug target in the treatment of organ fibrosis.