肺炎衣原体感染及炎症反应与冠心病的关系

Relationship between Chlamydia pneumoniae infections,inflammation and coronary heart disease

目的探讨肺炎衣原体感染、炎症反应与冠心病的关系。方法选择2014年1月-2016年12月于医院诊断及治疗的冠心病患者80例为研究对象,分为急性心肌梗死组40例,心绞痛组40例,另选择同期健康体检者40名为对照组;检测并分析各组白细胞介素-6(IL-6)、C-反应蛋白(CRP)、纤维蛋白原(Fg)以及肺炎衣原体特异性抗体IgM以及IgG水平的差异,分析IL-6、CRP、Fg与心绞痛危险评分的关系,分析肺炎衣原体特异性抗体与IL-6、CRP、Fg的关系。结果急性心肌梗死组IL-6、CRP及Fg水平高于心绞痛组及对照组,心绞痛组高于对照组(P<0.05);心绞痛患者随着危险分数的升高,IL-6、CRP及Fg水平也呈上升的趋势(P<0.05);急性心肌梗死组与心绞痛组肺炎衣原体特异抗体IgG阳性率高于对照组(P<0.05);IgG阳性患者IL-6及CRP水平高于阴性患者(P<0.05);Pearson相关分析结果显示,肺炎衣原体特异性抗体IgG阳性与IL-6、CRP及Fg呈正相关关系(r=0.441,0.472,0.395,P<0.05)。结论冠心病患者肺炎衣原体特异性抗体IgG水平升高,并且IgG与炎性指标有正相关关系,因此推断肺炎衣原体感染在冠心病的发生及发展过程中也发挥了重要的作用。

OBJECTIVE To discuss relationship between Chlamydia pneumoniae infections,inflammation and coronary heart disease.METHODS A total of 80 cases of patients with coronary heart disease from Jan.2014 to Dec.2016 were selected as study objects,and were divided into AMI group（40 cases）and angina pectoris group（40 cases）.Another 40 cases for healthy examination were selected as control group.IL-6,CRP,Fg and C.pneumoniae specific antibody IgG and IgM were detected,and the differences in three groups were compared.Relationship between IL-6,CRP,Fg with risk score of angina pectoris was analyzed.Correlation between IgG and IgM with IL-6,CRP and Fg were analyzed.RESULTSIL-6,CRP and Fg levels of AMI group were higher than those of angina pectoris group and control group,and those of angina pectoris group were higher than control group,which showed significant differences（P〈0.05）.In angina pectoris group,L-6,CRP and Fg increased with rising of risk score,which showed significant differences（P〈0.05）.Positive rates of C.pneumoniae specific antibody IgG of AMI group and angina pectoris group were higher than that of control group,which showed significant differences（P〈0.05）.IL-6 and CRP levels of cases with IgG（＋）were higher than those of cases with IgG（-）,which showed significant differences（P〈0.05）.Pearson correlation analysis showed that C.pneumoniae specific antibody IgG（＋）showed positive correlation with IL-6,CRP and Fg（r=0.441,0.472,0.395,all P〈 0.05）.CONCLUSIONIn patients with coronary heart disease,the level of C.pneumoniae specific antibody IgG is significantly increased,and there was a significant positive correlation between IgG and inflammatory indexes.Therefore,it is concluded that C.pneumoniae infection plays an important role in the occurrence and development of coronary heart disease.