切开挂线联合甲硝唑与左氧氟沙星对肛周脓肿感染患者病原菌及血浆内毒素水平的影响

Effects of incision hanging line combined with metronidazole and levofloxacin on pathogens and plasma endotoxin level in patients with perianal abscess infection

目的分析切开挂线联合甲硝唑、左氧氟沙星对肛周脓肿感染患者血浆内毒素水平及病原菌的影响。方法选择2015年9月-2016年9月期间医院收治的肛周脓肿感染患者70例,按照随机、对照、双盲试验原则分为试验组和对照组,每组各35例,对照组患者采用甲硝唑联合左氧氟沙星治疗,在对照组治疗基础上,试验组患者联合切开挂线治疗,观察分析病原菌、血浆内毒素、治疗有效率、复发率等指标评估临床疗效。结果治疗后,试验组患者真菌、金黄色葡萄球菌、大肠埃希菌病原菌菌落数均低于对照组(P<0.05);试验组患者血浆内毒素水平低于对照组(P<0.05);试验组患者治疗总有效率91.43%,高于对照组68.57%(P<0.05);试验组复发率为2.86%,低于对照组11.43%(P<0.05)。结论对肛周脓肿感染患者,切开挂线联合甲硝唑、左氧氟沙星治疗,有利于改善肛周病原菌数量,防止血浆内毒素水平升高,提高临床治疗效果,降低复发率,值得临床积极推广和应用。

OBJECTIVE To analyze the effects of incision hanging line combined with metronidazole and levofloxacin on pathogens and plasma endotoxin level in patients with perianal abscess infections.METHODS A total of 70 patients with perianal abscess infections enrolled in our hospital from Sep.2015 to Sep.2016 were selected,and were divided into observation group and control group according to randomized,controlled and double-blind trial principle,with 35 cases in each group.The patients in control group were treated with metronidazole and levofloxacin,on the basis of control group,the patients in observation group were treated with incision hanging line.The clinical efficacy was evaluated by pathogens,plasma endotoxin,treatment efficiency and recurrence rate.RESULTS After treatment,the numbers of pathogens of fungi,Staphylococcus aureus and Escherichia coli in observation group were lower than those in control group（P〈0.05）.The level of plasma endotoxin in observation group was lower than that in control group（P〈0.05）.The total effective rate was 91.43%in observation group,which was significantly higher than 68.57%in control group（P 〈0.05）.The recurrence rate was 2.86% in observation group,which was significantly lower than 11.43%in control group（P〈0.05）.CONCLUSION The incision hanging line combined with metronidazole and levofloxacin in the treatment of perianal abscess infection can improve the number of perianal pathogens,prevent the increase of plasma endotoxin level,improve the clinical therapeutic effect and reduce the recurrence rate,and thus can be promoted and applied in the clinical practice.