粘膜下注射不同液体在内镜下切除肠息肉中的应用

The application of different solution in submucosal injection during resection of elderly colorectal polyps

目的对比粘膜下注射甘油果糖和生理盐水在内镜下切除肠息肉中的效果。方法选择180例老年肠息肉患者进行内镜下高频电切除,随机分为甘油果糖组和生理盐水组,每组90例。观察进镜时间、手术时间、麻醉时间、麻醉药用量、住院时间及并发症情况。结果与生理盐水组相比,甘油果糖组患者的操作总时间(麻醉时间)和处理息肉时间均显著缩短(t=12.838,P=0.000;t=39.288,P=0.000),注射液体量和丙泊酚用量均显著减少(t=36.529,P=0.000;t=2.710,P=0.007),差异均具有统计学意义(P<0.05);两组患者的插镜至回盲部时间、术后并发症及平均住院时间相比,差异均无统计学意义(P>0.05)。结论甘油果糖是理想的老年肠息肉切除粘膜下注射药物。

Objective To compare the efficiency of different solution submucosal injection during endoscopic resection of colorectal polyps in elder patients. Methods 180 cases of elderly patients with colorectal polyps were treated with endoscopic high-frequency electric resection,and were randomly divided into glycerol fructose group（90 cases）and saline group （90 cases）. Duration of operating （anesthetic duration） and polyps processing ,submucosal injection volume ,the dosage of anesthetic drugs ,hospital stay and complications between two groups were documented. Results Compared with the saline group,the total operating time（anesthetic time）and treatment polyp time were significantly shortened of glycerol fructose group（t=12.838,P=0.000;t=39.288,P=0.000）,the injection volume and dosage of propofol were significantly decreased（t=36.529,P=0.000;t=2.710,P=0.007）,the difference was statistically significant（P〈0.05）. Time for insert lens to the ileo ,postoperative complications and average hospital stay time of the two groups were not significantly different （P〉0.05）. Conclusion Glycerol fructose is an ideal submucosal injection solution during elderly colorectal polyps endoscopic resection.