多奈哌齐改善帕金森病痴呆患者认知功能和日常生活能力的效果

Effect of Donepezil in Improving the Cognitive Function and Activity of Daily Living of Patients with Parkinson's Disease Dementia

目的观察多奈哌齐在改善帕金森病痴呆患者认知功能和日常生活能力中的效果。方法选择我院2015年3月至2016年12月期间收治的94例帕金森病痴呆患者随机均分为两组。对照组采用多巴丝肼治疗,观察组采用多奈哌齐联合多巴丝肼治疗,比较两组患者的日常生活能力、认知功能以及精神状态,观察两组治疗期间的不良反应。结果用药后,观察组的MMSE评分、Mo CA评分以及Barthel指数评分均显著高于对照组(P<0.05)。观察组的不良反应发生率为14.9%,对照组为8.5%,差异无统计学意义(P>0.05)。结论多奈哌齐应用于帕金森病痴呆患者,可改善患者的认知功能、日常生活能力以及精神状态。

Objective To explore the effect of donepezil in improving the cognitive function and activity of daily living of patients with Parkinson＇s disease dementia （PDD）. Methods 94 cases of patients with Parkinson＇s disease dementia admitted to our hospital ~om March 2015 to December 2016 were randomly divided into two groups equally. The control group was treated with levodopa and benserazide hydrochloride, while the observation group was treated with donepezil combined with levodopa and benserazide hydrochloride. The cognitive function, activity of daily living and mental state were compared between two groups, and the adverse reactions during treatment of two groups were observed. Results ARer medication, the scores of MMSE, MoCA and Barthel index of observation group were significantly higher than those of control group （P 〈0.05）. The incidence of adverse reactions was 14.9% in observation group, and 8.5% in control group, with no statistical difference （P〉0.05）. Conclusions Donepezil applied in patients with Parkinson＇s disease dementia can improve patients＇ cognitive function, activity of daily living and mental state.