两种检验方法在肺结核早期诊断中的应用比较

Comparison on the Application of Two Test Methods in the Diagnosis of Early Pulmonary Tuberculosis

目的观察两种检验方法在肺结核早期诊断中的应用价值。方法以我院2015年6月至2017年3月期间收治的54例肺结核早期患者为观察组,同期57例健康人群为对照组,两组均进行聚合酶链式反应(PCR)检验和皮肤结核菌素纯蛋白衍生物(PPD)检验。结果 PCR检验中,观察组阴性率为31.5%,对照组阴性率为94.7%;PPD检验中,观察组阴性率为59.3%,对照组阴性率为78.9%。观察组中,PCR检验的阳性率为68.5%,显著高于PPD检验的40.7%,差异有统计学意义(P<0.05)。ROC分析显示,PCR、PPD均对肺结核早期患者具有一定诊断价值(P<0.05),且PCR检验的诊断价值显著高于PPD检验。结论采用PCR检验诊断早期肺结核,准确性高,具有临床应用价值。

Objective To observe the application value of two test methods in the diagnosis of early pulmonary tuberculosis. Methods 54 cases of patients with early pulmonary tuberculosis in our hospital from June 2015 to March 2017 were selected as observation group, and 57 cases of healthy people at the same period were selected as control group. Both groups received polymerase chain reaction （PCR） examination and purified protein derivative tuberculin （PPD） examination. Results PCR examination showed that the negative rate was 31.5% in observation group, and 94.7% in control group; PPD examination showed that the negative rate was 59.3% in observation group, and 78.9% in control group. Among patients in observation group, the positive rate of PCR examination was 68.5%, significantly higher than 40.7% of PPD examination （P 〈0.05）. ROC analysis showed that both PCR examination and PPD examination had diagnostic value in patients with early tuberculosis （P 〈0.05）, and PCR examination had significantly higher diagnostic value than PPD examination. Conclusions PCR examination has high accuracy in the diagnosis of early pulmonary tuberculosis, which has clinical application value.