胺碘酮治疗急性心肌梗死伴高危快速型心律失常的疗效观察

Observation on the Clinical Effect of Amiodarone in the Treatment of Acute Myocardial Infarction Complicated with High-Risk Tachycardiac Arrhythmia

目的研究胺碘酮治疗急性心肌梗死伴高危快速型心律失常的效果。方法选择我院2016年3月至2017年6月间收治的急性心肌梗死伴高危快速型心律失常患者56例,根据治疗方法的不同分为两组。对照组27例患者实施常规对症疗法,观察组29例患者在常规对症疗法的基础上加用胺碘酮治疗。比较两组患者的治疗效果、不良反应发生率,以及治疗前后的心率、左室射血分数(LVEF)、左心室短轴缩短率(FS)。结果治疗48 h后,观察组的总有效率为100.00%,显著高于对照组的85.19%,差异有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。观察组治疗48 h后的LVEF和心率均显著优于对照组,差异有统计学意义(P<0.05)。结论胺碘酮用于急性心肌梗死伴高危快速型心律失常患者的治疗中效果显著,能快速缓解患者的心律失常症状,改善心功能。

Objective To study the effect of amiodarone in the treatment of acute myocardial infarction complicated with high-risk tachycardiac arrhythmia. Methods 56 cases of patients with acute myocardial infarction complicated with high-risk tachycardiac arrhythmia admitted to our hospital from March 2016 to June 2017 were selected and divided into two groups according to the treatment methods. 27 cases of control group received regular symptomatic treatment, while 29 cases of observation group received amiodarone on the basis of regular symptomatic treatment. The curative effect, incidence of adverse reactions, and the heart rate, left ventricular ejection fraction （LVEF）, left ventricular fractional shortening （FS） before and after treatment were compared between two groups. Results After treatment for 48 hours, the total effective rate of observation group was 100.00%, significantly higher than 85.19% of control group （P〈0.05）. No statistical difference was found between two groups in the incidence of adverse reactions （P〉0.05）. After treatment for 48 hours, the LEVF and heart rate of observation group were significantly better than those of control group （P〈0.05）. Conclusions Amiodarone has significant efficacy in the treatment of acute myocardial infarction complicated with high-risk tachycardiac arrhythmia, which can quickly relieve patients＇ arrhythmia symptoms, and improve patients＇ cardiac function.