左西孟坦联合血液净化治疗难治性心力衰竭的效果

Effect of Levosimendan associated with blood purification in the treatment of refractory heart failure

目的探讨左西孟坦联合血液净化治疗难治性心力衰竭的效果。方法选取2015年7月~2017年2月在我院急诊ICU接受治疗的80例难治性心力衰竭患者作为研究对象,采用单双号随机分组的方式分为对照组与治疗组,各40例。对照组患者在常规心力衰竭药物的基础上加用多巴酚丁胺联合托拉塞米和(或)呋噻米进行治疗,治疗组患者在常规心力衰竭药物的基础上加用左西孟联合血液净化治疗,比较两组患者的总有效率、心室射血分数(LVEF)、每分钟心排指数(CI)、NT-proBNP变化。结果治疗组的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗组治疗后的NT-proBNP水平低于对照组,LVEF、CI水平高于对照组,差异有统计学意义(P<0.05)。结论左西孟坦联合血液净化治疗难治性心力衰竭的疗效明显,值得在临床推广。

Objective To explore the effect of Levosimendan associated with blood purification in the treatment of re- fractory heart failure.Methods 80 patients with refractory heart failure who were treated in EICU of our hospital from July 2015 to February 2017 were selected and divided into the control group and the treatment group according to the method of odd and even random grouping,40 cases in each group.The control group was given Dobutamine Torasemide and （or） Furosemide on the basis of conventional heart failure drugs.The treatment group was treated with Levosimen- dan and blood purification on the basis of routine drugs treatment for heart failure.The level of leftventricular ejection fraction （LVEF）,cardiac output index （CI） and NT-proBNP were compared before and after treatment between the two groups.Results The total effective rate after treatment in the treatment group was significantly higher than that in the control group,with significant difference （P〈0.05）,the level of LVEF and CI after treatment in the treatment group was significantly higher than that in the control group,the level of NT-proBNP after treatment in the treatment group was lower than that in the control group,with significant difference （P〈0.05）.Conclusion The effect of Levosimendan associ- ated with blood purification in the treatment of refractory heart failure is significant,which is worth applying in clinical.