乳腺癌患者MVD VEGF与Ki-67淋巴结转移的相关性分析

目的探讨乳腺癌组织MVD、VEGF与Ki-67、淋巴结转移等临床病理学特征的相关性。方法采用免疫组化SP法检测108例乳腺浸润性导管癌组织中MVD、VEGF、ER、PR、HER-2、Ki-67表达情况，并结合临床病理学特征进行相关性分析。结果乳腺浸润性导管癌组织中MVD均值为（22．85±8．063），VEGF、Ki-67阳性高表达率分别为56．5％、685％，ER、PR、HER-2阳性表达率分别为648％、593％、38．0％；MVD与Ⅺ-67表达、淋巴结转移成正相关（P〈0．05，r=0．279，r=0．216），与年龄、ER、PR、HER-2、肿瘤大小无关；VEGF表达与Ki-67表达、淋巴结转移成正相关（P〈0．05，r=0571，r=0．202），与年龄、ER、PR、HER-2、肿瘤大小无关；MVD与VEGF成正相关（P〈0．05，r=0．481）。结论联合检测MvD、VEGF可评估Ki-67表达、淋巴结转移风险。

Objective To investigate the correlation between MVD, VEGF and Ki-67, lymph node metastasis and other clinicopathological features in breast cancer. Methods Immunohistochemical SP method was used to detect the expression ofMVD, VEGF, ER, PR, HER-2 and Ki- 67 in 108 cases of breast invasive ductal carcinoma. The correlation analysis was made with the clinicopathological features. Results The mean MVD of breast invasive ductal carcinoma was 22.85 ± 8.063, and the positive expression rates of VEGF and Ki-67 were 56.5% and 68.5% respectively. The positive expression rates ofER, PR and HER-2 were 64.8%, 59.3% and 38.0%; MVD was positively correlated with Ki-67 and lymph node metastasis （P〈0.05, r=0.279, r=0.216 ） , which was not related to age, ER, PR, HER-2 and tumor size. VEGF expression was positively correlated with Ki-67 and lymph node metastasis （ P〈0.05, r=0.571, r=0.202 ） , which was not related to age, ER, PR, HER-2 and tumor size. MVD was positively correlated with VEGF （ P〈0.05, R=0.481 ） . Conclusion Combined detection of MVD and VEGF can assess Ki-67 expression and the risk of lymph node metastasis.