盐酸羟考酮缓释片和硫酸吗啡缓释片治疗重度癌痛的效果研究

Effect of Oxycodone Hydrochloride Sustained Release Tablets and Morphine Sulfate Sustained Release Tablets in Treating Severe Cancer Pains

目的研究对重度癌痛患者采用盐酸羟考酮缓释片和硫酸吗啡缓释片进行治疗的临床效果。方法选取我院收治的癌症晚期重度疼痛患者92例进行研究,随机分为两组,每组各46例,对照组给予患者硫酸吗啡缓释片,实验组给予盐酸羟考酮缓释片,对比两组患者的止痛效果以及不良反应发生情况。结果实验组患者的止痛起效时间短于对照组,且实验组中患者的不良反应发生率较低,P<0.05,比较差异具有统计学意义。结论盐酸羟考酮缓释片和硫酸吗啡缓释片对于癌症晚期重度疼痛患者均有镇痛作用,但是,盐酸羟考酮缓释片的起效时间较短,起效迅速,且能够降低不良反应的发生情况。

Objective To study the clinical effect of oxycodone hydrochloride sustained release tablets and morphine sulfate sustained release tablets in patients with severe pain. Methods 92 patients with advanced severe cancer pain in our hospital were selected and randomly divided into two groups with 46 patients in each group. The control group was given morphine sustained release tablets, and the experimental group was given oxycodone hydrochloride sustained release tablets. The analgesic effect and adverse reaction of the two groups were compared. Results The onset time of analgesia in the experimental group was significantly shorter than that in the control group, and the incidence of adverse reactions in the experimental group was significantly lower than that of the control group. The difference was statistically significant（P 〈 0.05）. Conclusion Oxycodone hydrochloride sustained release tablets and morphine sustained- release tablets have analgesic effects in patients with advanced severe cancer pain. However, oxycodone hydrochloride sustained release tablets have a short onset time, rapid onset of action, and can reduce adverse effects.