普通肝素防治胎盘早剥早产儿凝血功能障碍/弥散性血管内凝血的效果观察

Effect of Unfractionated Heparin in Preventing and Treating Coagulation Dysfunction/Disseminated Intravascular Coagulation in Premature Infants With Placental Abruption

目的研究普通肝素防治胎盘早剥早产儿凝血功能障碍/弥散性血管内凝血的效果。方法选择我院80例胎盘早剥早产儿,时间为2015年1月—2017年1月,按照给予普通肝素剂量不同分为两组,每组40例,常规剂量治疗为对照组,加大剂量治疗为实验组,观察患儿的临床效果。结果实验组患儿的凝血功能较对照组强,血小板计数优于对照组,无明显的不良反应,对照组有3例患儿出现新生儿黄疸、2例出现坏死性小肠结肠炎,两组差异有统计学意义(P<0.05)。结论普通肝素防治胎盘早剥早产儿凝血功能障碍/弥散性血管内凝血的效果非常好,可提高患儿的凝血功能,避免不良反应,有利于患儿健康成长。

Objective To study the effect of unfractionated heparin on preventing and treating coagulation dysfhnction/disseminated intravascolar coagulation in premature infants with placental abruption. Methods 80 cases of premature placental abruption in our hospital was selected from January 2015 to January 2017. In accordance with the different doses of unfractionated heparin, they were divided into two groups, 40 cases in each group. The routine dose treatment was the control group, and the dose treatment was increased in the experimental group, and the clinical effect of the children was observed. Results In the experimental group, the coagulation function of the experimental group was stronger than that of the control group, and the platelet count was superior to that of the control group, with no obvious adverse reactions. Neonatal jaundice appeared in 3 cases and necrotizing enterocolitis in 2 cases, the difference between the two groups was statistically significant （P 〈 0.05）. Conclusion Unfractionated heparin prevention and treatment of premature placental abruption coagulation dysfunction / disseminated intravascular coagulation is very good, which can improve children＇s blood coagulation. In addition, unfractionated heparin to avoid adverse reactions, which is conducive to the healthy growth of children.