健脾和胃汤治疗小儿脾胃虚弱型厌食症的临床效果及对其体内微量元素水平的影响

Clinical effect of Jianpi Hewei Decoction on infantile anorexia of spleen and stomach deficiency and its influence on trace elements

目的:探讨自拟健脾和胃汤治疗小儿脾胃虚弱型厌食症的临床效果及对BMI、血锌(Zn^(2+))、血钙(Ca^(2+))、中医症候积分的影响。方法:将我院收治的112例脾胃虚弱型厌食症患儿根据数字表法随机分为对照组56例和观察组56例,对照组给予健胃消食片和复合维生素B片,观察组给予我院自拟的健脾和胃汤。对比两组治疗前后BMI、血Zn^(2+)、血Ca^(2+)、中医证候积分,并比较两组临床疗效。结果:两组治疗后的血Zn^(2+)和血Ca^(2+)水平与治疗前比较明显较高(P<0.05);观察组治疗后血Zn^(2+)和血Ca^(2+)水平明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后的BMI与治疗前比较明显较高,中医症候积分与治疗前比较明显较低,差异有统计学意义(P<0.05);观察组治疗后BMI值升高和中医症候积分降低程度更为明显,差异有统计学意义(P<0.05)。观察组临床总有效率和对照组比较明显较高,差异有统计学意义(P<0.05)。结论:健脾和胃汤能明显改善小儿脾胃虚弱型厌食症的临床症状和体征,改善体内微量元素钙、锌含量,近期临床效果确切,远期效果仍需要深入研究。

Objective： To investigate clinical efficacy of Jianpi Hewei Decoction in treatment of infantile anorexia due to spleen and stomach defieiency and its effect on BMI, Zn^2＋, Ca^2＋ and TCM syndrome score. Methods： One hundred and twelve patients with infantile anorexia due to spleen and stomach deficiency were randomly divided into control group and observation group, with 56 cases in each group. Control group was given Jianwei Xiaoshi Tablet and compound vitamin B, while observation group was treated with self-made Jianpi Hewei Decoction. BMI, blood Zn2＋, blood Ca2＋ and TCM syndrome scores were analyzed before and after treatment, and clinical efficacy in the two groups was compared. Results： Blood Zn2＋ and Ca2＋ levels in the two groups were significantly higher after treatment than those before treatment （P〈0.05）. Blood Zn^2＋ and Ca^2＋ levels in the observation group were signfficantly higher than those in the control group after treatment （P〈0.05）. BMI in the two groups was significantly increased and TCM syndrome score was significantly decreased compared with before treatment （P〈0.05）. The increment of BMI and the reduction of TCM syndrome score in the observation group were significantly obvious compared with the control group （P〈0.05）. The overall response rate in the observation group was significantly higher than that in the control group （P〈0.05）. Conclusion： Jianpi Hewei Decoction can improve clinical symptoms and signs in infantile anorexia due to spleen and stomach deficiency, improve the levels of trace elements such as calcium and zinc, and exert obvious clinical effect. Long-term effect needs further studies for confirmation.